Molecular and Cell Biological Aspects of Learning: Toward a Theory of Memory

Shashoua, Victor E.

doi:10.1016/b978-0-12-008303-9.50008-6

Cited by 35 publications

(9 citation statements)

References 113 publications

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“…On the basis of these previous findings of general and specific protein changes in brain cells as a function of change in behavior (for reviews, see Hyd6n [1978], Shashoua [1982], and Matthies et al, [1975]) and the data obtained by the present study we would like to suggest the following interpretation.…”

Section: Discussionsupporting

confidence: 75%

Modification of membrane‐bound proteins of the hippocampus and entorhinal cortex by change in behavior in rats

Hydén

Lange

1983

J of Neuroscience Research

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Rats were trained in an instrumental task for 2 X 25 min during 1 day and 4 days and compared with active controls with respect to membrane-bound proteins solubilized by chloral hydrate and fractionated on polyacrylamide gels. Then 30-micrograms samples of the hippocampus and entorhinal cortex were labeled by 14C- and 3H-valine. The distribution of the stained electrophoretogram was recorded by microdensitometry. The results show that the 1-day training induced an increased synthesis of a membrane protein fraction of 50,000 mol wt already present in the brain membrane proteins of active controls. Training for 4 days resulted in an overall stimulation of the hippocampal membrane protein fractions, especially in the higher-molecular-weight range. The entorhinal cortex showed two stimulated membrane protein fractions, 50,000 and 120,000 mol wt. Together with previous studies, this study makes it probable that training to establish a new behavior induces a modulation of both soluble and membrane-bound protein patterns in the hippocampus and the entorhinal cortex with a time phase retardation for the latter.

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Section: Discussionsupporting

confidence: 75%

Modification of membrane‐bound proteins of the hippocampus and entorhinal cortex by change in behavior in rats

Hydén

Lange

1983

J of Neuroscience Research

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“…In part, this is reflected in cocaine dreams (Gawin & Ellinwood 1988;Gold, Wash ton & Dackis 1985;Shashoua 1982). Direct neurochemical changes involve the functioning of dopamine, norepinephrine, serotonin, and opioid peptides.…”

Section: Discussionmentioning

confidence: 97%

“…However, with continued use more significant and less readily reversible nervous, endocrine, and possibly immune system adaptations take place (Gawin & Ellinwood 1988;Verebey & Gold 1985). Specific biochemical and anatomical changes occur that are the substrate for learning and memory (Shashoua 1982). With continued abuse or dependence, the neuronal and hormonal adaptations are of such magnitude and complex ity that they may require a long time for full return of normal function (approximately six months to three years) and they may never recover fully (Beasley 1987).…”

Section: Cocaine-inducedmentioning

confidence: 99%

Improvement of Cocaine-Induced Neuromodulator Deficits by the Neuronutrient Tropamine™

Trachtenberg¹,

Blum

1988

Journal of Psychoactive Drugs

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“…In previous investigations (Shashoua, 1982), the ependymins, which are major constituents of the brain ECF protein fraction, were found to bind quantitatively to Con A-Sepharose affinity resins. Columns of such resins also remove the protease activity from ECF.…”

Section: Esterase Activity Studiesmentioning

confidence: 88%

Extracellular Fluid Proteins of Goldfish Brain: Evidence for the Presence of Proteases and Esterases

Shashoua

Holmquist

1986

Journal of Neurochemistry

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Preparations of enriched fractions of extracellular fluid (ECF) proteins from goldfish brain were found to contain protease(s) and esterase(s). The N‐substituted furanacryloyl (FA) peptides FA‐Phe‐Gly‐Gly and FA‐Phe‐OMe were used as model substrates for determining protease and esterase activity, respectively, in a spectro‐photometric assay. Studies of the profile of substrate specificity and identification of the types of compounds that were effective as inhibitors showed that these ECF enzymes have some distinctive properties. GSH, but not GSSG, and EDTA inhibited the protease(s) without influencing the esterase(s), whereas l‐1‐tosylamide‐2‐phenylethylchloromethyl ketone blocked both protease and esterase activites of ECF. Most of the protease and esterase properties of ECF could be bound to concanav‐alin A‐Sepharose affinity chromatographic columns in association with ependymin—a brain extracellular protein. These observations indicate that ECF may contain a metalloprotease(s) and raise the possibility that the ependymins might be a substrate for these ECF enzymes.

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Molecular and Cell Biological Aspects of Learning: Toward a Theory of Memory

Cited by 35 publications

References 113 publications

Modification of membrane‐bound proteins of the hippocampus and entorhinal cortex by change in behavior in rats

Modification of membrane‐bound proteins of the hippocampus and entorhinal cortex by change in behavior in rats

Improvement of Cocaine-Induced Neuromodulator Deficits by the Neuronutrient Tropamine™

Extracellular Fluid Proteins of Goldfish Brain: Evidence for the Presence of Proteases and Esterases

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