Molecular and Cellular Changes in Breast Cancer and New Roles of lncRNAs in Breast Cancer Initiation and Progression

Kumar, Maneesh; DeVaux, Rebecca; Herschkowitz, Jason I.

doi:10.1016/bs.pmbts.2016.09.011

Cited by 30 publications

(20 citation statements)

References 99 publications

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“…Intriguingly the largest class of lncRNA functions in epigenetic modifications through associating with chromatin remodeling complexes including PRC1, PRC2 and the LSD1 DNA methylation protein complex. LncRNA epigenetic functions have been well reviewed [ 111 – 113 ]. The importance of lncRNAs to early stage breast cancer progression is emerging.…”

Section: Noncoding Rnamentioning

confidence: 99%

“…HOTAIR expression is known to be elevated in primary breast tumors and depletion can inhibit tumor invasiveness [ 38 , 114 ]. In depth reviews of HOTAIR function expand on its role in tumorigenesis and metastasis [ 113 , 115 ], and now HOTAIR expression may be an early indicator of those early lesions that may progress. As previously described, Johnson et al performed a longitudinal study wherein they compared patient matched normal and DCIS and followup DCIS that progressed to invasive disease [ 38 ].…”

Section: Noncoding Rnamentioning

confidence: 99%

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Beyond DNA: the Role of Epigenetics in the Premalignant Progression of Breast Cancer

DeVaux

Herschkowitz

2018

J Mammary Gland Biol Neoplasia

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Ductal Carcinoma in Situ (DCIS) is an early breast cancer lesion that is considered a nonobligate precursor to development of invasive ductal carcinoma (IDC). Although only a small subset of DCIS lesions are predicted to progress into a breast cancer, distinguishing innocuous from minacious DCIS lesions remains a clinical challenge. Thus, patients diagnosed with DCIS will undergo surgery with the potential for radiation and hormone therapy. This has led to a current state of overdiagnosis and overtreatment. Interrogating the transcriptome alone has yet to define clear functional determinants of progression from DCIS to IDC. Epigenetic changes, critical for imprinting and tissue specific development, in the incorrect context can lead to global signaling rewiring driving pathological phenotypes. Epigenetic signaling pathways, and the molecular players that interpret and sustain their signals, are critical to understanding the underlying pathology of breast cancer progression. The types of epigenetic changes, as well as the molecular players, are expanding. In addition to DNA methylation, histone modifications, and chromatin remodeling, we must also consider enhancers as well as the growing field of noncoding RNAs. Herein we will review the epigenetic interactions that have been uncovered in early stage lesions that impact breast cancer progression, and how these players may be utilized as biomarkers to mitigate overdiagnosis and overtreatment.

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Section: Noncoding Rnamentioning

confidence: 99%

Section: Noncoding Rnamentioning

confidence: 99%

Beyond DNA: the Role of Epigenetics in the Premalignant Progression of Breast Cancer

DeVaux

Herschkowitz

2018

J Mammary Gland Biol Neoplasia

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“…Nuclear lncRNAs impact gene regulation through recruiting or blocking transcription factors, supporting chromatin looping around enhancer regions, or through interaction with histone‐modifying complexes to impact global chromatin architecture . LncRNAs are also found to impact messenger RNA (mRNA) stability, translation, and splicing can function as micro RNA sponges, and as multiple protein complex scaffolds . It is now appreciated that lncRNAs play critical roles in development, and are often dysregulated in disease progression .…”

Section: Introductionmentioning

confidence: 99%

“…LncRNAs are also found to impact messenger RNA (mRNA) stability, translation, and splicing can function as micro RNA sponges, and as multiple protein complex scaffolds . It is now appreciated that lncRNAs play critical roles in development, and are often dysregulated in disease progression . In breast cancer, an expression panel of lncRNAs has been shown to perform as well as the Prediction Analysis of Microarray 50 at classifying breast cancer intrinsic subtypes and predicting overall survival .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, lncRNAs can function as oncogenes as exemplified by HOTAIR which supports tumor cell invasion, cell proliferation, and metastasis in breast cancer . Despite increasing evidence that lncRNAs are functional molecules, the analysis of the majority of lncRNAs is preliminary and has not resulted in a clear pattern of expression in models of progression …”

Section: Introductionmentioning

confidence: 99%

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Long noncoding RNA BHLHE40‐AS1 promotes early breast cancer progression through modulating IL‐6/STAT3 signaling

DeVaux

Ropri

Grimm

et al. 2020

J of Cellular Biochemistry

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Ductal carcinoma in situ (DCIS) is a nonobligate precursor to invasive breast cancer. Only a small percentage of DCIS cases are predicted to progress; however, there is no method to determine which DCIS lesions will remain innocuous from those that will become invasive disease. Therefore, DCIS is treated aggressively creating a current state of overdiagnosis and overtreatment. There is a critical need to identify functional determinants of progression of DCIS to invasive ductal carcinoma (IDC). Interrogating biopsies from five patients with contiguous DCIS and IDC lesions, we have shown that expression of the long noncoding RNA BHLHE40-AS1 increases with disease progression.BHLHE40-AS1 expression supports DCIS cell proliferation, motility, and invasive potential. Mechanistically, BHLHE40-AS1 modulates interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3) activity and a proinflammatory cytokine signature, in part through interaction with interleukin enhancer-binding factor 3. These data suggest that BHLHE40-AS1 supports early breast cancer progression by engaging STAT3 signaling, creating an immune-permissive microenvironment.

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Assessment of Trizol-Based Method for Isolating Small RNAs from Plasma

Uyen,

Luan,

Thuy

et al. 2023

IFMBE Proceedings

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Molecular and Cellular Changes in Breast Cancer and New Roles of lncRNAs in Breast Cancer Initiation and Progression

Cited by 30 publications

References 99 publications

Beyond DNA: the Role of Epigenetics in the Premalignant Progression of Breast Cancer

Beyond DNA: the Role of Epigenetics in the Premalignant Progression of Breast Cancer

Long noncoding RNA BHLHE40‐AS1 promotes early breast cancer progression through modulating IL‐6/STAT3 signaling

Assessment of Trizol-Based Method for Isolating Small RNAs from Plasma

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