Molecular and cellular genetics of non-Hodgkin lymphoma: Diagnostic and prognostic implications

Pratap, Suraj; Scordino, Teresa

doi:10.1016/j.yexmp.2018.11.008

Cited by 20 publications

(15 citation statements)

References 64 publications

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“…In these cases, FISH or sequencing assessments of the cell population can indicate the diagnosis in addition to also having a prognostic value. These changes can be represented by Tumor protein p53 TP53 and cyclin-dependent kinase Inhibitor 2A CDKN2A mutations as markers of transformation [41], or can assist in differentiating between activated peripheral B-cell (ABC) and germinal center B-cell (GCB) types of DLBCL [42]. Moreover, certain translocations can be identified by FISH with the additional value of providing orientation in the diagnosis of a certain type of lymphoma [43].…”

Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases

Griesel

Desmirean

Esterhuizen

et al. 2020

JCM

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Introduction: Fine needle aspiration (FNA) is frequently the first noninvasive test used for the diagnostic workup of lymphadenopathy. There have been many studies showing its usefulness, especially in conjunction with other techniques for the diagnosis of lymphoma, but it remains inferior to histological examination. The data regarding this subject have mostly been reported mostly from first-world countries, but are scarce for emerging economies. Thus, the current study assesses the agreement between fine needle aspiration flow cytometry (FNA FC) and histology in the aforementioned region. Material and Methods: We conducted a retrospective study including the FNA FC adenopathy diagnoses made between January 2011 and December 2016 at the Tygerberg Hospital, Cape Town, South Africa. Additional variables included were the histological diagnosis, sex and age of the included patients. Results: In the descriptive part of the current study, 269 FNA FC samples were included. The most frequent diagnoses made on these were represented by B-cell lymphoma, reactive adenopathy, no abnormality detected (NAD), and non-hematological malignancy. In the analytical part of the current study, there were 115 cases included that had both valid FNA FC and histological diagnoses. It could be observed that FNA FC can correctly diagnose B-cell lymphoma in most cases, but it is a poor diagnostic tool especially for Hodgkin lymphoma in this setting as only a four-color flow cytometer was available for diagnosis. Moreover, FNA FC diagnosis of reactive adenopathy and of no abnormalities detected was shown to frequently hide a malignant disease. Conclusion: In countries with scarce resources, FNA FC represents a useful diagnostic tool in the case of B-cell lymphoma, but may misdiagnose reactive adenopathy. Thus, FNA FC should be used in a case-specific manner, in addition to as a screening tool, with the knowledge that in cases with a high clinical suspicion of lymphoma, histological diagnosis is a necessity.

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Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases

Griesel

Desmirean

Esterhuizen

et al. 2020

JCM

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“…Non-Hodgkin B-cell lymphomas (NHL) are the most common hematological malignancies worldwide and the fifth most common cancer. It is a heterogeneous group of lymphoid neoplasms, including latent types such as marginal-zone lymphomas (MZL), follicular lymphomas, and aggressive diseases such as diffuse large B-cell lymphoma (DLBCL) and Burkitt’s lymphoma, with complex etiopathology, a variety of symptomatology and clinical courses, and consequently different therapeutic approaches [ 1 ]. MZL are indolent diseases that arise from the small B cells of the marginal zone, which surrounds the lymph node and lies outside of the mantle zone.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Infection and Non-Hodgkin B-Cell Lymphoma: Interactions between Pathogen, Host and the Tumor Environment

Biernat

Wróbel

2021

IJMS

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Non-Hodgkin B-cell lymphomas (NHL) are a heterogeneous group of lymphoid neoplasms with complex etiopathology, rich symptomatology, and a variety of clinical courses, therefore requiring different therapeutic approaches. The hypothesis that an infectious agent may initiate chronic inflammation and facilitate B lymphocyte transformation and lymphogenesis has been raised in recent years. Viruses, like EBV, HTLV-1, HIV, HCV and parasites, like Plasmodium falciparum, have been linked to the development of lymphomas. The association of chronic Helicobacter pylori (H. pylori) infection with mucosa-associated lymphoid tissue (MALT) lymphoma, Borrelia burgdorferi with cutaneous MALT lymphoma and Chlamydophila psittaci with ocular adnexal MALT lymphoma is well documented. Recent studies have indicated that other infectious agents may also be relevant in B-cell lymphogenesis such as Coxiella burnettii, Campylobacter jejuni, Achromobacter xylosoxidans, and Escherichia coli. The aim of the present review is to provide a summary of the current literature on infectious bacterial agents associated with B-cell NHL and to discuss its role in lymphogenesis, taking into account the interaction between infectious agents, host factors, and the tumor environment.

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“…2 The World Health Organization's (WHO) classification is currently the most used system. 3 The 2016 revision of the WHO classification includes the definition of more than 50 NHL types and a few temporary types. 4 Genital system involvement of non-Hodgkin lymphoma can be seen in two ways.…”

Section: Introductionmentioning

confidence: 99%

Uterine cervical involvement of non‐Hodgkin lymphoma: Rare cause of postcoital bleeding

Birge

Bakır

Dinc

et al. 2021

Clinical Case Reports

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Molecular and cellular genetics of non-Hodgkin lymphoma: Diagnostic and prognostic implications

Cited by 20 publications

References 64 publications

Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases

Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases

Bacterial Infection and Non-Hodgkin B-Cell Lymphoma: Interactions between Pathogen, Host and the Tumor Environment

Uterine cervical involvement of non‐Hodgkin lymphoma: Rare cause of postcoital bleeding

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