Molecular and Circulatory Expression of Insulin Growth Factors in Indian Females with Advanced Cervical Cancer

Sharma, Manoj; Satyam, Abhigyan; Agarwal, Abhishek; Khan, Rehan; Rajappa, Medha; Sharma, Alpana

doi:10.7314/apjcp.2012.13.12.6475

Cited by 9 publications

(9 citation statements)

References 37 publications

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“…Population studies indicate a relationship between serum IGF1 level and cancer risk. Individuals with higher circulating IGF1 concentration have increased risk of colorectal, breast, lung and other cancer [39,40,41,42,43]. Experimental investigations provide evidence that IGF1 have regulatory roles in cell proliferation and apoptosis [12,16].…”

Section: Discussionmentioning

confidence: 99%

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Lu¹,

Wang²,

He³

et al. 2015

Cell Physiol Biochem

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Background/Aims: IGF1 is a key regulator in cell proliferation and apoptosis, and the 3' un-translated region (3'UTR) of the gene plays an important role in gene expression. For the first time, we explored the relationship between polymorphisms in the IGF1 3'UTR region and the risk of childhood acute lymphoblastic leukemia (ALL). Methods: Questionnaires were applied to collect epidemiological data. The genotypes of IGF1 polymorphisms were tested in a population of 744 ALL patients and 1088 cancer-free controls utilizing Taqman. Cell functional studies included real-time PCR, cell culture and transfection and luciferase assays. Results: We found that rs6214 homozygous AA genotype and rs6218 homozygous CC genotype were significantly associated with increased risk of childhood ALL. In addition, rs6218 CC genotype was associated with increased level of IGF1 mRNA in bone marrow, and the mutation in rs6218 led to aberrant binding capacity of hsa-miR-603 and hsa-miR-3941 in the 3'UTR of IGF1. Conclusion: Polymorphisms of rs6214 and rs6218 in the 3'UTR of IGF1 are associated with childhood ALL susceptibility, and the polymorphism of rs6218 is related with IGF1 expression at mRNA level.

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Section: Discussionmentioning

confidence: 99%

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Lu¹,

Wang²,

He³

et al. 2015

Cell Physiol Biochem

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“…Growth factors are also included in chemokines and TGFs, IGFs, GMCSF and VEGF are examples of growth factors which influence carcinogenesis, tumor growth as well as metastasis (Tabibzadeh et al, 1989;Platanias, 2007;Sharma M et al, 2012).…”

Section: Structure and Functions In Generalmentioning

confidence: 99%

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Paradkar¹,

Joshi²,

Mertia³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cytokine research is currently at the forefront in cancer research. Deciphering the functions of these multiple small molecules, discovered within the cell and in intercellular spaces, with their abundance and pleotrophism, was initially a great challenge. Advances in analytical chemistry and molecular biology have made it possible to unravel the pathophysiological functions of these polypeptides/proteins which are called interleukins, chemokines, monokines, lymphokines and growth factors. With more than 5 million women contracting cervical cancer every year this cancer is a major cause of mortality and morbidity the world over, particularly in the developing countries. In more than 95% of cases it is associated with human papilloma virus (HPV) infection which is persistent, particularly in those with a defective immune system. Although preventable, the mere magnitude of prevalence of HPV in the world population makes it a dominating current health hazard. The discovery of cytokine dysregulation in cervical cancer has spurted investigation into the possibility of using them as biomarkers in the early diagnosis of cases at high risk of developing cancer. Their critical role in carcinogenesis and progression of cervical cancer is now being revealed to a great extent. From diagnostics to prognosis, and now with a possible role in therapeutics and prevention of cervical cancer, the cytokines are being evaluated in all anticancer approaches. This review endeavours to capture the essence of the astonishing journey of cytokine research in cervical neoplasia.

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“…It was also indicated in an important review by Pollak et al that increasing IGF-1 levels are associated with an increased risk of cancer since somatic cells of individuals with higher levels of IGF-1 may show slightly higher proliferation rates and have a slightly increased chance of survival in the presence of genetic damage because of the antiapoptotic effects of IGF-1 (model of stepwise accumulation of genetic damage leading to carcinogenesis) (1). The only unclear aspect of the association being discussed is that some researchers claim it is positive (61,62,81) and others claim the contrary is the case (64–66) and even though there is a stronger body of evidence supporting the former, the latter should not be discarded.…”

Section: Igf Axis and Hpv-related Cervical Cancermentioning

confidence: 99%

“…Development of cervical cancer affects a small percentage of HR-HPV-infected women and often takes decades after infection, suggesting that HR-HPV is a necessary but not sufficient cause of cervical cancer (81). Thus, other cofactors are necessary for progression from cervical HR-HPV infection to cancer.…”

Section: Other Factors In Cervical Cancermentioning

confidence: 99%

IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (Review)

Durzyńska

2014

Oncology Reports

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The insulin-like growth factor (IGF) axis promotes the growth of cells, tissues and organs. IGF-1 is mainly produced in the liver but is also secreted from local tissues. In the circulation, IGF-1 is bound to insulin-like binding proteins (IGFBPs), and when released it activates the insulin-like growth factor receptor (IGF-1R). The signal is further transmitted by intracellular signaling pathways leading to gene expression that regulates, among others, cell proliferation and survival. This review presents the IGF axis in the context of cell transformation and cancer development. Aspects involving IGF-1 deficiency and protection from cancer are also briefly described. Furthermore, human papillomaviruses (HPVs) interplaying with IGF axis components in cervical cancer development are described. These small dsDNA viruses are divided into low-risk and high-risk HPVs with regard to the potency of their oncogenic actions; they mainly infect epithelial or mucosal cells. Special attention is drawn to expression of two major HPV oncogenes (E6 and E7) initiating and maintaining cervical carcinogenesis, which is a multistep and multifactorial process; therefore, involvement of additional factors such as mitochondrial DNA changes, sex hormones, retinoic and folic acids are also discussed. Finally, IGF axis components and HPV oncogenes as targets in anticancer treatment are presented which include IGF-1R downregulation, RNA interference and anti-HPV therapeutic vaccines. The review concludes that despite an enormous advancement in research on IGF and HPV-related cancers, more molecular studies and clinical trials are needed before commercialized therapies are widely available for oncology patients.

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Molecular and Circulatory Expression of Insulin Growth Factors in Indian Females with Advanced Cervical Cancer

Cited by 9 publications

References 37 publications

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (Review)

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