Molecular and clinical aspects of connective tissue

Krieg, T; Hein, Rüdiger; Hatamochi, Atsushi; Aumailley, Monique

doi:10.1111/j.1365-2362.1988.tb02400.x

Cited by 52 publications

(15 citation statements)

References 142 publications

(112 reference statements)

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“…Existing scar tissue due to previous surgical interventions consists of a different extracellular matrix structure 29,30 resulting from a change in the quantity and type of collagens and noncollagenous components, when compared with regular breast tissue, and is well detectable by mammoDPC, as shown in Figure 3. This is caused by the high sensitivity of the technique to the scattering power of the investigated sample.…”

Section: Discussionmentioning

confidence: 99%

A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

Hauser¹,

Wang²,

Ra³

et al. 2014

Investigative Radiology

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Section: Discussionmentioning

confidence: 99%

A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

Hauser¹,

Wang²,

Ra³

et al. 2014

Investigative Radiology

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“…With regard to the central task of collagen providing the tensile strength of tissue, impaired collagen concentrations have been ascribed a role in the development of hernias as well. Previous studies illustrated altered collagen I/III ratios in patients with osteogenesis imperfecta, Marfan's and Ehlers-Danlos syndromes, and these syndromes were regarded as disorders of collagen metabolism [9,10,28]. The alterations may occur in the collagen chain synthesis or in the hydroxylation of collagens, as well as abnormal fibril formation or interaction with other ECM components [28,29].…”

Section: Discussionmentioning

confidence: 99%

Abnormal Collagen I to III Distribution in the Skin of Patients with Incisional Hernia

Klinge¹,

Si²,

Zheng³

et al. 2000

Eur Surg Res

189

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The surgical mesh-free repair of incisional hernias has to face recurrence rates of up to 50%. Apart from technical faults this is probably due to collagen metabolic disorders, known to play an important role in the development of inguinal hernia. In particular an altered ratio of collagen types I and III with an increase in collagen type III has been claimed to reduce the mechanical strength of connective tissues. Therefore, we investigated the content of collagen types I and III in the skin of patients with incisional hernia (n = 7) and recurrent incisional hernia (n = 5) in comparison to controls with healthy skin (n = 7) and normal skin scar (n = 7) both by immunohistochemistry and Western blot analysis. Both immunohistochemistry and Western blot analysis revealed a decrease in the ratio of collagen I/III due to a concomitant increase in collagen III. The patients with incisional hernias and with recurrent incisional hernias showed a ratio of 1.0 ± 0.1 and 0.8 ± 0.1, respectively, whereas the controls exhibit a ratio of 2.1 ± 0.2 in healthy skin and of 1.2 ± 0.2 in normal skin scar, respectively. The decrease was highly significant (p < 0.01) between the patients with either primary or recurrent hernia and the controls or the normal scar, as well as between controls and normal scar, whereas there was not any significant difference between primary and recurrent hernia (p > 0.05). Our data for the first time confirmed that the presence of incisional hernia is accompanied by impaired collagen synthesis in the skin. The decreased tensile strength of collagen type III may play a key role in the development of incisional hernias. Furthermore, it might explain the high recurrence rates of hernia repair by simple closure, as a repetition of the primarily failing technique, and the improvement by the additional use of alloplastic material.

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“…Collagen degradation and abnormal elastin accumulation are visible in photoaged skin (Krieg et al, 1988).…”

Section: Ros-induced Oxidative Damage To the Structural Dermal Proteimentioning

confidence: 99%

Oxidation events and skin aging

Kammeyer

Luiten

2015

Ageing Research Reviews

726

563

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Molecular and clinical aspects of connective tissue

Cited by 52 publications

References 142 publications

A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

Abnormal Collagen I to III Distribution in the Skin of Patients with Incisional Hernia

Oxidation events and skin aging

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