2018
DOI: 10.3390/ijms19051299
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Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism

Abstract: Venous thromboembolism (VTE) is a common and potentially life-threatening condition which includes both deep-vein thrombosis (DVT) and pulmonary embolism (PE). VTE has a significant clinical and epidemiological impact in the elderly, and its incidence increases to more than 1% per year in older patients, suggesting the presence of specific age-related risk factors in this population. Immobilization seems to predominate as the main cause in patients admitted for medical acute illness in medicine wards, and ther… Show more

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Cited by 16 publications
(11 citation statements)
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“…Cancer, chronic heart failure, diabetes mellitus, chronic obstructive pulmonary disease, genetic factors and immobilization are risk factors for DVT, particularly in older patients . In agreement with these previous studies, the present findings show that immobilization and cancer were significant risk factors for DVT.…”
Section: Discussionsupporting
confidence: 92%
“…Cancer, chronic heart failure, diabetes mellitus, chronic obstructive pulmonary disease, genetic factors and immobilization are risk factors for DVT, particularly in older patients . In agreement with these previous studies, the present findings show that immobilization and cancer were significant risk factors for DVT.…”
Section: Discussionsupporting
confidence: 92%
“…This is a possible, very important source of bias, considering that dementia often goes undiagnosed when patients are evaluated outside a geriatric or neurologic specialty context, especially in the oldest old [ 69 ]. Few studies have investigated the cognitive function with standardized scales (e.g., MMSE), and there is little information about the potential influence of comorbidities (e.g., metabolic syndrome, hypertension, renal failure) on sUA and therefore on cognitive function [ 70 , 71 ]. Considering the complex and strong interaction between cognitive function, physical status, and comorbidities [ 72 ], it could be interesting to explore the specific influence of a nutritional marker such as UA in patients with different forms of dementia.…”
Section: Study Limitations At the Basis Of Conflicting Evidencementioning
confidence: 99%
“… 31 , 32 Interestingly, PD is associated with increased deep vein thrombosis. 33 The purinergic G-protein coupled receptor P2RY12 is a therapeutic target of the clinically approved anti-thrombotic drugs cangrelor and clopidogrel. 34 Kloss et al.…”
Section: Discussionmentioning
confidence: 99%