Molecular and Extract-Based Diagnostics in Meat Allergy

Hilger, Christiane; Hemmer, Wolfgang; Swoboda, Ines; Morisset, M.; Fischer, Jörg; Tripathi, Anju; Platts-Mills, Thomas A.E.; Biedermann, Tilo

doi:10.1007/978-3-319-42499-6_16

Cited by 2 publications

(2 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it remains unclear whether the intense itching that can occur with schistosome species pathogenic to humans or with cercaria of duck schistosomes (swimmer's itch) are caused by or contributed to by IgE Ab to oligosaccharides. The situation regarding the mammalian oligosaccharide alpha‐gal is completely different because in this case there is extensive evidence that severe symptoms both immediate during cetuximab infusions, and as part of delayed reactions occurring 2–6 hours after eating mammalian meat, are directly related to specific IgE Ab 8,17‐21 . The immediate reactions to cetuximab are best explained by the presence of the oligosaccharide alpha‐gal attached to the asparagine at position 43 in the Fab region of the heavy chain of this monoclonal antibody 22 .…”

Section: Symptoms Related To Ige Ab Responses To Oligosaccharide Epitopes On Different Groups Of Allergensmentioning

confidence: 99%

Carbohydrate epitopes currently recognized as targets for IgE antibodies

Platts‐Mills

Hilger

Jappe

et al. 2021

Allergy

View full text Add to dashboard Cite

Until recently, glycan epitopes have not been documented by the WHO/IUIS Allergen Nomenclature Sub-Committee. This was in part due to scarce or incomplete information on these oligosaccharides, but also due to the widely held opinion that IgE to these epitopes had little or no relevance to allergic symptoms. Most IgE-binding glycans recognized up to 2008 were considered to be "classical" cross-reactive carbohydrate determinants (CCD) that occur in insects, some helminths and throughout the plant kingdom. Since 2008, the prevailing opinion on lack of clinical relevance of IgEbinding glycans has been subject to a reevaluation. This was because IgE specific for the mammalian disaccharide galactose-alpha-1,3-galactose (alpha-gal) was identified as a cause of delayed anaphylaxis to mammalian meat in the United States, an observation that has been confirmed by allergists in many parts of the world. Several experimental studies have shown that oligosaccharides with one or more terminal alpha-gal How to cite this article: Platts-Mills TA, Hilger C, Jappe U, et al. Carbohydrate epitopes currently recognized as targets for IgE

show abstract

Section: Symptoms Related To Ige Ab Responses To Oligosaccharide Epitopes On Different Groups Of Allergensmentioning

confidence: 99%

Carbohydrate epitopes currently recognized as targets for IgE antibodies

Platts‐Mills

Hilger

Jappe

et al. 2021

Allergy

View full text Add to dashboard Cite

show abstract

“…Some subjects can also react to beef, presumably because IgE in these subjects can also bind to and cross-link Bos d 6 (bovine serum albumin) [21]. Because sensitization to cat underlies the development of the allergy, some have advocated that the name 'cat-pork syndrome' would be more apt [23][24][25]. Other forms of meat allergy occurring as a consequence of albumin sensitization via the respiratory tract have also been reported.…”

Section: Pork-cat Syndromementioning

confidence: 99%

Red meat allergy in children and adults

Wilson

Platts-Mills

2019

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

Purpose of Review: To highlight recent advances in our understanding of the clinical features, prevalence and pathophysiology of red meat allergy.Recent findings: Allergic reactions to red (ie, mammalian) meat have historically been considered rare and described primarily in young atopic children. It is now clear that red meat allergy is not uncommon in some parts of the world in other age groups. Strikingly, the majority of these cases relate to specific IgE to galactose-α-1,3-galactose (α-Gal), an oligosaccharide of nonprimate mammals. The mechanism of sensitization in this syndrome relates to bites of certain hard ticks and the clinical reactions often have a delay of 3-6 hours. An additional form of red meat allergy relates to inhalant sensitization to mammalian proteins. The best characterized example involves cat-sensitized subjects with specific IgE to cat serum albumin who can react to ingested pork because of cross-sensitization to pork serum albumin.Summary: Red meat allergy is more common than previously appreciated and relates to at least three different forms that are distinguished by mechanisms of sensitization and have characteristic clinical and immunologic features.

show abstract

Molecular and Extract-Based Diagnostics in Meat Allergy

Cited by 2 publications

References 67 publications

Carbohydrate epitopes currently recognized as targets for IgE antibodies

Carbohydrate epitopes currently recognized as targets for IgE antibodies

Red meat allergy in children and adults

Contact Info

Product

Resources

About