2006
DOI: 10.1002/ppul.20443
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Molecular and functional changes of pulmonary surfactant in response to hyperoxia

Abstract: Surfactant comprises phosphatidylcholine (PC) together with anionic phospholipids, neutral lipids, and surfactant proteins SP-A to-D. Its composition is highly specific, with dipalmitoyl-PC, palmitoyl-myristoyl-PC, and palmitoyl-palmitoleoyl-PC as its predominant PC species, but with low polyunsaturated phospholipids. Changes in pulmonary metabolism and function in response to injuries depend on their duration and whether adaptation can occur. We examined in rats prolonged (7 days) versus acute (2 days) exposu… Show more

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Cited by 18 publications
(15 citation statements)
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References 38 publications
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“…2). This is consistent with data on newly synthesized PC in adult mouse, rat, and human lung secretions, showing that it initially contributes a lower fraction to surf-PC and that molecular refinement occurs during surfactant recycling (5,8,17). However, whereas in adult organisms such refinement requires up to 24 h, our data show that in neonatal rat lungs refinement occurs within 3 h, indicating a much faster turnover, which is not affected by rhuKGF, betamethasone, or their combination.…”
Section: Resultssupporting
confidence: 81%
See 1 more Smart Citation
“…2). This is consistent with data on newly synthesized PC in adult mouse, rat, and human lung secretions, showing that it initially contributes a lower fraction to surf-PC and that molecular refinement occurs during surfactant recycling (5,8,17). However, whereas in adult organisms such refinement requires up to 24 h, our data show that in neonatal rat lungs refinement occurs within 3 h, indicating a much faster turnover, which is not affected by rhuKGF, betamethasone, or their combination.…”
Section: Resultssupporting
confidence: 81%
“…Other PC species are low in surfactant but of high concentration in lung tissue. They contribute to membrane homeostasis or as eicosanoid or docosanoid precursors, e.g., palmitoyl-arachidonoyl-PC (PC16:0/20:4) and palmitoyl-docosahexaenoyl-PC (PC16:0/22:6) (6,7,17).…”
mentioning
confidence: 99%
“…In general, these studies demonstrate that hyperoxia stimulates surfactant synthesis [44][45][46] but impairs surfactant function [47] . Moreover, both VEGF and the expression of VEGF receptors are decreased by hyperoxia [48,49] .…”
Section: Discussionmentioning
confidence: 99%
“…These genes were also not identified by a similar DNA microarray analysis of the hyperoxic mouse lungs [14]. However, these genes have been reported to be changed in the lung exposed to hyperoxia [24][25][26][27][28]. The discrepancy may be due to the sensitivity of the detection methods or the absence of the genes on the arrays.…”
Section: Discussionmentioning
confidence: 94%