Molecular and Functional Imaging in Radiation Oncology

Jeraj, Robert; Meyerand, M. Elizabeth

doi:10.1007/978-0-387-36744-6_4

Cited by 3 publications

(2 citation statements)

References 160 publications

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“…The rapid expansion of functional and molecular imaging in the last decade [39,40] and its seemingly infinite capabilities [41] have led to speculations that biological imaging information could be used as a template for biological conformal radiation therapy -the process most often termed ''dose painting'' [42,43]. While the idea is extremely appealing, many obstacles need to be overcome related to the general limitations of the imaging techniques [44,45], but also related to the increased uncertainties when one wants to explore imaging information on a per-voxel basis to determine the extent of biological heterogeneities [46,47].…”

Section: Target Definition Incorporating Biological Imagingmentioning

confidence: 99%

The physical basis and future of radiation therapy

Bortfeld

Jeraj²

2011

BJR

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ABSTRACT. The remarkable progress in radiation therapy over the last century has been largely due to our ability to more effectively focus and deliver radiation to the tumour target volume. Physics discoveries and technology inventions have been an important driving force behind this progress. However, there is still plenty of room left for future improvements through physics, for example image guidance and four-dimensional motion management and particle therapy, as well as increased efficiency of more compact and cheaper technologies. Bigger challenges lie ahead of physicists in radiation therapy beyond the dose localisation problem, for example in the areas of biological target definition, improved modelling for normal tissues and tumours, advanced multicriteria and robust optimisation, and continuous incorporation of advanced technologies such as molecular imaging. The success of physics in radiation therapy has been based on the continued ''fuelling'' of the field with new discoveries and inventions from physics research. A key to the success has been the application of the rigorous scientific method. In spite of the importance of physics research for radiation therapy, too few physicists are currently involved in cutting-edge research. The increased emphasis on more ''professionalism'' in medical physics will tip the situation even more off balance. To prevent this from happening, we argue that medical physics needs more research positions, and more and better academic programmes. Only with more emphasis on medical physics research will the future of radiation therapy and other physics-related medical specialties look as bright as the past, and medical physics will maintain a status as one of the most exciting fields of applied physics.

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Section: Target Definition Incorporating Biological Imagingmentioning

confidence: 99%

The physical basis and future of radiation therapy

Bortfeld

Jeraj²

2011

BJR

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“…Similar to perfusion MRI, DCE-CT can be used to assess perfusion. Even though CT can provide very high resolution, the microvessels are too small to be imaged directly but their increased density translates in vivo to increased tumour perfusion and blood volume [18].…”

Section: Evidence-based Neuroimagingmentioning

confidence: 99%

Clinical applications of imaging biomarkers. Part 1. The neuroradiologist's perspective

Smith¹

2011

BJR

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Breast imaging: A survey

Sree

Acharya³

et al. 2011

WJCO

139

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Breast cancer is the second leading cause of death in women. It occurs when cells in the breast start to grow out of proportion and invade neighboring tissues or spread throughout the body. Mammography is one of the most effective and popular modalities presently used for breast cancer screening and detection. Efforts have been made to improve the accuracy of breast cancer diagnosis using different imaging modalities. Ultrasound and magnetic resonance imaging have been used to detect breast cancers in high risk patients. Recently, electrical impedance imaging and nuclear medicine techniques are also being widely used for breast cancer screening and diagnosis. In this paper, we discuss the capabilities of various breast imaging modalities.

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Molecular and Functional Imaging in Radiation Oncology

Cited by 3 publications

References 160 publications

The physical basis and future of radiation therapy

The physical basis and future of radiation therapy

Clinical applications of imaging biomarkers. Part 1. The neuroradiologist's perspective

Breast imaging: A survey

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