2019
DOI: 10.1111/ahg.12367
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Molecular and geographical heterogeneity of hemoglobinopathy mutations in Azerbaijanian populations

Abstract: With the carrier rate of 4%–8.6%, β‐thalassemia is one of the most prevalent hereditary disorders in Azerbaijan. Taking into consideration the high frequency of β‐thalassemia as well as the occurrences of several other hemoglobinopathies, we conducted a large genotyping study to investigate the mutational background of common hemoglobinopathies in the country. Α‐ and β‐globin genes were evaluated in the carriers of mutations identified via hematological indices and hemoglobin fractions (n = 1,757). Genotyping … Show more

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Cited by 6 publications
(1 citation statement)
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“…Another notable example of regional variation is relevant to codon 8, which shows its highest frequencies in Sulaimani at the East, and decreases in frequency to the West and North of the region. Codon 8 (−AA), labeled a Turkish/Mediterranean mutation, has its highest frequency worldwide in the country of Azerbaijan, where it constitutes nearly one-third of βthalassemia alleles(Aliyeva et al 2020). It is also a common mutation in Iranian Azerbaijan province bordering the Sulaimani province on the East (Hosseinpour Feizi et al…”
mentioning
confidence: 99%
“…Another notable example of regional variation is relevant to codon 8, which shows its highest frequencies in Sulaimani at the East, and decreases in frequency to the West and North of the region. Codon 8 (−AA), labeled a Turkish/Mediterranean mutation, has its highest frequency worldwide in the country of Azerbaijan, where it constitutes nearly one-third of βthalassemia alleles(Aliyeva et al 2020). It is also a common mutation in Iranian Azerbaijan province bordering the Sulaimani province on the East (Hosseinpour Feizi et al…”
mentioning
confidence: 99%