Molecular and histopathological evaluation of the efficacy of Saponified and Freund’s incomplete adjuvanted paratuberculosis killed vaccine in murine model
Abstract:Johne's disease (JD) is caused by Mycobacterium avium subspecies paratuberculosis (MAP). Vaccination is regarded as the only cost effective method for controlling JD. Experimental trial for 11 months was carried out by dividing mice into four different groups. Group I-saponified MAP killed vaccine; Group II-Freund's incomplete adjuvant (FIA) MAP killed vaccine; Group III-saponin adjuvant control; Group IV-FIA control. Mice of all the groups were challenged with 10 8 colony forming unit live MAP organisms on 40… Show more
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