Molecular and Immunological Characterization of the Fimbriae of Porphyromonas gingivalis

Activation of human gingival epithelial cells by cell-surface components of black-pigmented bacteria: augmentation of production of interleukin-8, granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor and expression of intercellular adhesion molecule 1

“…intermedia, possess various virulence factors on their cell surfaces, such as LPS [5,6] and ®mbriae [16,17]. The immunobiological activities of these factors have been studied extensively in relation to the pathogenesis of periodontal diseases.…”

Prevalence of Porphyromonas gingivalis fimA genotypes in Japanese children

“…In particular, FimA fimbriae, filamentous components on the cell surface, are thought to play important roles in the colonization and invasion of periodontal tissue (7,8). The P. gingivalis fimA gene has been classified into six variants (types I through V and Ib) based their nucleotide sequences (9)(10)(11). A polymerase chain reaction (PCR) method with fimA typespecific primer sets has been developed to differentiate the six types of fimA genes of P. gingivalis in saliva and dental plaque samples collected from periodontitis patients (11,12).…”

Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine‐specific protease

“…A number of bacterial species have also been shown to bind specifically to various extracellular matrix (ECM) proteins (for a review, see Patti et al, 1994;Wadströ m et al, 1993;Westerlund and Korhonen, 1993). P. gingivalis possesses fine fibrillar proteinaceous appendages, fimbriae, which are arranged peritrichously, emerging from the cell surface (Hamada et al, 1994). P. gingivalis fimbriae were also found to bind to ECM components, such as collagen, fibronectin, and laminin (Kontani et al, 1996), and adherence of the organism is mediated by the fibrillar proteinaceous appendages (Hamada et al, 1994;Naito et al, 1993).…”

“…P. gingivalis possesses fine fibrillar proteinaceous appendages, fimbriae, which are arranged peritrichously, emerging from the cell surface (Hamada et al, 1994). P. gingivalis fimbriae were also found to bind to ECM components, such as collagen, fibronectin, and laminin (Kontani et al, 1996), and adherence of the organism is mediated by the fibrillar proteinaceous appendages (Hamada et al, 1994;Naito et al, 1993). Furthermore, it was shown that fimbrilin, a monomeric subunit protein of fimbriae, bound to a salivary proteins (Nagata et al, 1997).…”