2023
DOI: 10.3389/fimmu.2023.1243997
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Molecular and immunological mechanisms of clonal evolution in multiple myeloma

Stefan Forster,
Ramin Radpour,
Adrian F. Ochsenbein

Abstract: Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of clonal plasma cells in the bone marrow (BM). It is known that early genetic mutations in post-germinal center B/plasma cells are the cause of myelomagenesis. The acquisition of additional chromosomal abnormalities and distinct mutations further promote the outgrowth of malignant plasma cell populations that are resistant to conventional treatments, finally resulting in relapsed and therapy-refractory terminal stages of MM. … Show more

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Cited by 11 publications
(1 citation statement)
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“… 7 Second, interleukin-6 (IL-6) is a potent human myeloma cell growth factor and an important component of MM pathogenesis and progression. 8 IL-6 can induce thrombocytosis through thrombopoietin, 9 and may induce ET. IL-6 may be a common link between MM and ET.…”
mentioning
confidence: 99%
“… 7 Second, interleukin-6 (IL-6) is a potent human myeloma cell growth factor and an important component of MM pathogenesis and progression. 8 IL-6 can induce thrombocytosis through thrombopoietin, 9 and may induce ET. IL-6 may be a common link between MM and ET.…”
mentioning
confidence: 99%