“…These models include yeast, worms, fruit flies, and zebrafish. 36 , 37 Mammalian models have historically been limited to studying forms of ARS-mediated dominant peripheral neuropathy 38 , 39 , 40 but are increasingly employed for modeling ARS-mediated recessive diseases, including models for Dars1 , 41 , 42 Iars1 43 , Fars2 , 44 Sars2 , 45 and Wars2 . 46 Moving forward, mouse models will be critical tools to understand why certain tissues are particularly sensitive to loss-of-function variants in specific ARS genes, as these questions must be addressed in a model organism with relevant tissue types.…”