Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium

Yap, Sook Peng; Shen, Ping; Li, J.; Lee, Lawrence S.; Yong, Eu Leong

doi:10.1016/j.jep.2007.05.029

Cited by 39 publications

(18 citation statements)

References 27 publications

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“…In contrast, the same methanol soluble bioactive agents induce growth promoting effects through the upregulation of epidermal growth factor receptor/mitogen-activated protein kinase signaling pathways in a model of HER-2 + breast cancer (27). Furthermore, organic solvent fractionated extracts from Epimedium brevicornum containing the prenylflavone breviflavone B have been demonstrated to exhibit inhibitory effects on ER-α expression, in addition to on the growth of ER-α + breast cancer cells in vitro and in vivo (28)(29)(30). The growth inhibitory effect of non-fractionated aqueous extract from EG in the present study and the growth modulatory effects of organic solvent fractionated extracts from different Epimedium species in previous studies, suggest that EG has a pleiotropic effect, which is likely due to the presence of distinct constitutive bioactive components.…”

Section: Discussionmentioning

confidence: 99%

The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer

Telang¹,

Gou²,

Katdare

et al. 2017

Oncology Letters

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Abstract. The Luminal A subtype of breast cancer expresses the estrogen receptor (ER)-α and progesterone receptor (PR), but not the human epidermal growth factor receptor (HER)-2 oncogene. This subtype of breast cancer responds to endocrine therapy involving the use of selective estrogen receptor modulators and/or inhibitors of estrogen biosynthesis. However, these therapeutic agents are frequently associated with long-term systemic toxicity and acquired tumor resistance, emphasizing the need to identify non-toxic alternative treatments for chemo-endocrine therapy responsive breast cancer. The present study utilized the human mammary carcinoma-derived, ER + /PR + /HER-2 -MCF-7 cell line as a model of the Luminal A subtype of breast cancer to examine the growth inhibitory effect of the Chinese nutritional herb Epimedium grandiflorum (EG) and determine the mechanisms underlying this effect. MCF-7 cells maintained in a serum-depleted culture medium retained their ability to grow in response to 17β-estradiol (E 2 ). Treatment of the MCF-7 cells with EG resulted in dose-dependent inhibition of E 2 -promoted growth. Mechanistically, EG inhibited E 2 -promoted cell cycle progression through G 1 stage arrest and modulated the cellular metabolism of E 2 , increasing the formation of the anti-proliferative metabolites 2-hydroxyestrone and estriol. Long-term treatment of MCF-7 cells with EG inhibited E 2 -promoted anchorage independent growth, a surrogate in vitro biomarker of tumorigenesis. In conclusion, the results of the present study demonstrate the growth inhibitory effects of EG on MCF-7 cells and identified clinically relevant mechanistic leads for its anti-tumorigenic efficacy. IntroductionMetastatic breast cancer is one of the leading causes of breast-cancer associated mortality in the United States, and the American Cancer Society (Atlanta, GA, USA) projections for breast cancer incidence and mortality rates estimate 246,660 newly diagnosed cases of invasive breast cancer and 40,450 metastatic breast cancer-associated mortalities in women in 2017 (1). These figures emphasize the requirement for a more precise molecular classification of breast cancer for subtype-specific targeted therapy, in addition to the necessity to identify novel, non-toxic and efficacious modalities as alternatives for cancer prevention and therapy.The global gene expression profiling of breast cancer has led to the identification of molecularly distinct subtypes. Patients with the molecular subtype Luminal A express estrogen receptor-α (ER)-α and progesterone receptor (PR), and they lack the expression of human epidermal growth factor receptor-2 (HER-2). Patients with this subtype respond to endocrine-based targeted therapy, such as selective ER modulators and specific small molecule inhibitors of estrogen biosynthesis (2-4). However, long-term endocrine-based therapy has been associated with adverse systemic toxicity, acquired tumor resistance and the emergence of drug resistant cancer stem cells that compromise therapeutic efficacy and ...

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Section: Discussionmentioning

confidence: 99%

The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer

Telang¹,

Gou²,

Katdare

et al. 2017

Oncology Letters

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“…Several studies have analyzed the effects of various herbal supplements and medications. Cell cycle analysis has revealed that the stimulation of proliferation may be associated with a marked increase in the replication of MCF-7 cells, with the effects being similar to that of human estradiol [22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Retrospective study of MRI images to examine the effects of estrogen supplementation on breast tissue: A pilot study in Asian Taiwan

Leung

Huang²,

Wu³

et al. 2013

Health

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MRI provides a highly sensitive technique for early detection of abnormal breast tissue. It is useful for identifying a status of proliferation, angiogenesis, and microvascular permeability, which may indicate early breast neoplasm formation. We retrospectively studied 2005 breast MRI images from Taiwanese women and classified them as either healthy or unhealthy according to BI-RADS categories. A subgroup of our study patients had received estrogen supplements, containing estrogen components or phytoestrogen, for at least 3 months. These patients' images were also classified into the healthy and unhealthy groups. These two groups were compared and a significant difference was found between them (P < 0.002). Comparison of the MRI images also identified certain cases that demonstrated a typical estrogen/phytoestrogen effect or a withdrawal effect. The overuse of estrogen or phytoestrogen supplements can increase breast glandular tissue proliferation, as reflected on MRI images. Such proliferation may increase the patient's risk of future breast cancer.

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“…(Berberidaceae) has been proven to possess efficacy on osteoporosis, cardiovascular diseases, and to improve sexual function and immunoregulation (Yap et al, 2007;Zhang et al, 2007;Song et al, 2008). ICA is the major pharmacological active component of this herb.…”

Section: Research Articlementioning

confidence: 99%

Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K/AKT-eNOS signaling pathway

Duan

Huang

et al. 2013

Pharmaceutical Biology

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Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium

Cited by 39 publications

References 27 publications

The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer

The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer

Retrospective study of MRI images to examine the effects of estrogen supplementation on breast tissue: A pilot study in Asian Taiwan

Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K/AKT-eNOS signaling pathway

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