2021
DOI: 10.1002/ps.6481
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Molecular and pharmacological characterization of biogenic amine receptors from the diamondback moth, Plutella xylostella

Abstract: BACKGROUD Insect biogenic amines play important roles in mediating behavioral and physiological processes. They exert their effects by binding to biogenic amine receptors (BARs), which are specific receptor proteins in the G‐protein‐coupled receptor superfamily. BAR genes have been cloned and characterized from multiple model insects, including Drosophila melanogaster, Anopheles gambiae, Bombyx mori, Apis mellifera and Tribolium castaneum. However, relatively little work has addressed the molecular properties,… Show more

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Cited by 11 publications
(14 citation statements)
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“…Except for AaOAα1-R , all other receptors showed an expression pattern characterized by high levels of transcript in eggs, followed by a decline in larval stages and then high levels in pupae and adults. A similar dynamic expression pattern was observed in Plutella xylostella , in which both OA and TA receptors showed the highest expression levels in eggs and pupae, compared with larvae and adult [ 57 ]. Furthermore, in D .…”
Section: Discussionsupporting
confidence: 54%
“…Except for AaOAα1-R , all other receptors showed an expression pattern characterized by high levels of transcript in eggs, followed by a decline in larval stages and then high levels in pupae and adults. A similar dynamic expression pattern was observed in Plutella xylostella , in which both OA and TA receptors showed the highest expression levels in eggs and pupae, compared with larvae and adult [ 57 ]. Furthermore, in D .…”
Section: Discussionsupporting
confidence: 54%
“…Importantly, we found the toxicity activity of bifenazate to this destructive pest, suggesting it could be viewed as an alternative insecticide to control P. xylostella . Previous studies revealed that P. xylostella had evolved high resistance to various classes of insecticides, and sublethal selective pressure could promote the evolution of insecticide resistance in different insects [ 21 , 22 , 23 ]. Additionally, it is known that the identification of sublethal pesticide-responsive genes is required to help us better understand molecular mechanisms of insecticide action and the potential resistance of target insects [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…To meet this opportunity, determining the molecular and pharmacological data of OAR subtypes is an important step. OARs have been characterized in D. melanogaster [ 33 , 40 , 54 ], Bombyx mori [ 55 , 56 ], Periplaneta americana [ 57 , 58 ], A. mellifera [ 41 , 59 , 60 ], N. lugens [ 42 , 49 ], and P. xylostella [ 43 , 46 , 61 , 62 ]. Here, we cloned three OARs from C. chilonis , investigated their expression profiles, and pharmacologically characterized them.…”
Section: Discussionmentioning
confidence: 99%
“…Investigating the properties of OARs can contribute to understand the potential functions of octopaminergic systems in insects. Although the β-adrenergic-like OAR family has been characterized in Drosophila melanogaster [ 40 ], Apis mellifera [ 41 ], Nilaparvata lugens [ 42 ], and Plutella xylostella [ 43 ], the molecular information, expression patterns and pharmacological properties of the β-adrenergic-like OAR family from C. chilonis remain poorly known. The β-adrenergic-like OAR family generally has three subtypes, including Octβ1R, Octβ2R, and Octβ3R.…”
Section: Introductionmentioning
confidence: 99%