Molecular and Phylogenetic Study of Bm86 Gene Ortholog from Hyalomma excavatum Tick from Tunisia: Taxonomic and Immunologic Interest

Saïd, Mourad Ben

doi:10.4172/2161-1041.1000154

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…marginatum marginatum and Hy. scupense ticks [ 191 ]. Analysis of obtained amino acid sequences showed a high diversity of 33–34% in Bm86 and Hy.…”

Section: Anaplasmosis Control In Africamentioning

confidence: 99%

“…Analysis of obtained amino acid sequences showed a high diversity of 33–34% in Bm86 and Hy. excavatum orthologues (He86-A1/A2/A3), implying a reduction in the efficacy of the Bm86-based commercial and experimental vaccines [ 191 ]. A limited 10.2% amino acid diversity between Hd86-A1 used in the experimental vaccine against Hy.…”

Section: Anaplasmosis Control In Africamentioning

confidence: 99%

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Anaplasma Species in Africa—A Century of Discovery: A Review on Molecular Epidemiology, Genetic Diversity, and Control

Kolo

2023

Pathogens

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Anaplasma species, belonging to the family Anaplasmataceae in the order Rickettsiales, are obligate intracellular bacteria responsible for various tick-borne diseases of veterinary and human significance worldwide. With advancements in molecular techniques, seven formal species of Anaplasma and numerous unclassified species have been described. In Africa, several Anaplasma species and strains have been identified in different animals and tick species. This review aims to provide an overview of the current understanding of the molecular epidemiology and genetic diversity of classified and unclassified Anaplasma species detected in animals and ticks across Africa. The review also covers control measures that have been taken to prevent anaplasmosis transmission on the continent. This information is critical when developing anaplasmosis management and control programs in Africa.

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“…marginatum marginatum and Hy. scupense ticks [ 191 ]. Analysis of obtained amino acid sequences showed a high diversity of 33–34% in Bm86 and Hy.…”

Section: Anaplasmosis Control In Africamentioning

confidence: 99%

Section: Anaplasmosis Control In Africamentioning

confidence: 99%

Anaplasma Species in Africa—A Century of Discovery: A Review on Molecular Epidemiology, Genetic Diversity, and Control

Kolo

2023

Pathogens

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“…Amino acid sequence comparison between Bm86 and H. excavatum orthologues He86-A1/A2/A3 revealed high diversity (33–34%), which could decrease the efficacy of vaccination by commercial and experimental vaccines based on Bm86. However, there was limited (10.2%) amino-acid diversity between Hd86-A1 used in an experimental vaccine against H. scupense and He86-A1/A2/A3, suggesting that the Hd86-A1 vaccine candidate might be more appropriate to target the H. excavatum tick than the corresponding Bm86 vaccines [ 153 ].…”

Section: Anti-tick Vaccines In Africamentioning

confidence: 99%

Inspiring Anti-Tick Vaccine Research, Development and Deployment in Tropical Africa for the Control of Cattle Ticks: Review and Insights

et al. 2022

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Ticks are worldwide ectoparasites to humans and animals, and are associated with numerous health and economic effects. Threatening over 80% of the global cattle population, tick and tick-borne diseases (TTBDs) particularly constrain livestock production in the East, Central and Southern Africa. This, therefore, makes their control critical to the sustainability of the animal industry in the region. Since ticks are developing resistance against acaricides, anti-tick vaccines (ATVs) have been proposed as an environmentally friendly control alternative. Whereas they have been used in Latin America and Australia to reduce tick populations, pathogenic infections and number of acaricide treatments, commercially registered ATVs have not been adopted in tropical Africa for tick control. This is majorly due to their limited protection against economically important tick species of Africa and lack of research. Recent advances in various omics technologies and reverse vaccinology have enabled the identification of many candidate anti-tick antigens (ATAs), and are likely to usher in the next generation of vaccines, for which Africa should prepare to embrace. Herein, we highlight some scientific principles and approaches that have been used to identify ATAs, outline characteristics of a desirable ATA for vaccine design and propose the need for African governments to investment in ATV research to develop vaccines relevant to local tick species (personalized vaccines). We have also discussed the prospect of incorporating anti-tick vaccines into the integrated TTBDs control strategies in the sub-Saharan Africa, citing the case of Uganda.

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Molecular and Phylogenetic Study of Bm86 Gene Ortholog from Hyalomma excavatum Tick from Tunisia: Taxonomic and Immunologic Interest

Cited by 2 publications

References 23 publications

Anaplasma Species in Africa—A Century of Discovery: A Review on Molecular Epidemiology, Genetic Diversity, and Control

Anaplasma Species in Africa—A Century of Discovery: A Review on Molecular Epidemiology, Genetic Diversity, and Control

Inspiring Anti-Tick Vaccine Research, Development and Deployment in Tropical Africa for the Control of Cattle Ticks: Review and Insights

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