Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: A case-control study

Cuberos, Viviana; Pérez, J. Corrales; López, César Julián; Castro, Felipe A.; González, Leonor Victoria; Correa, Luis Alfonso; Sanclemente, Gloria; Gaviria, Ángela; Müller, Martin; Sánchez, Gloria Inés

doi:10.1016/j.jcv.2006.04.003

Cited by 41 publications

(33 citation statements)

References 34 publications

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“…They are seen in cases of Heck disease, squamo-papular lesions that consist of multiple papules on the oral mucosa associated with HPV-13, -32, and -55. 40,41 These lesions tend to occur in children and young adults and regress over time. These bodies are also seen in oral warts/condyloma without dysplasia that have been referred to as oral bowenoid lesions.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus-associated oral intraepithelial neoplasia

2013

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This study evaluated an unusual subset of oral epithelial dysplasia for the presence of transcriptionally active high-risk HPV subtypes and to further characterize the histological criteria for this condition. There were 20 cases diagnosed as epithelial dysplasia with marked apoptosis of the anterior oral cavity. Clinical and followup data were collected and histopathological features were documented. Immunoperoxidase studies were performed for p16 and in situ hybridization studies were performed for low-and high-risk HPV sub-types. Gender-and site-matched controls of conventional moderate-to-severe oral epithelial dysplasia were similarly evaluated using immunoperoxidase studies for p16 and in situ hybridization; the number of apoptotic cells for study and control cases was counted at two different tissue sites. There were 17 men and 3 women with a median age of 56 years. Seventeen lesions were described as white and five were described as rough or papillary. Thirteen were located on the lateral or ventral tongue, some extending onto the floor of the mouth. Epithelial hyperplasia with marked karyorrhexis and apoptosis were present in all the cases, along with features of conventional oral epithelial dysplasia. A statistically significant number of apoptotic cells were identified in the study cases when compared with controls (P40.0001). Twenty cases were positive for high-risk HPV by in situ hybridization and all 19 nineteen cases evaluated for p16 demonstrated overexpression. Two patients were diagnosed with squamous cell carcinomas and one patient developed recurrent disease. We report a subset of oral epithelial dysplasia that occurs mostly in adult men on the ventral or lateral tongue and is positive for high-risk HPV and for p16. We propose use of the term 'HPV-associated Oral Intraepithelial Neoplasia' to characterize these lesions of the oral cavity for consistency in nomenclature with HPV-associated lesions of the lower anogenital tract. One case recurred and one developed invasive cancer. Keywords: HPV apoptotic oral epithelial dysplasia; koilocytic dysplasiaIn the United States, smoking frequency has decreased by 16% and the overall number of cases of cancer of the oral cavity and pharynx has fallen by 18% since 1975. 1 However, rates of cancers of the oral tongue, base of tongue, and palatine tonsils have continued to rise by 2-4% among younger men. 2,3 This may, in part, be explained by the increased prevalence of a subset of oropharyngeal carcinoma associated with human papillomavirus (HPV), mostly HPV-16. 4-7 Importantly, p16 overexpression is noted in almost all HPV-associated head and neck cancers and indicates that the virus is transcriptionally active. Patients with HPV-positive, p16-positive oropharyngeal carcinomas are slightly younger than those with tumors not associated with HPV and show improved survival. 8,9 It is generally believed that HPV has only a minor role in squamous cell carcinoma of the anterior oral cavity, because it has been identified in only 2.9-5.9% of cases and the beha...

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Section: Discussionmentioning

confidence: 99%

Human papillomavirus-associated oral intraepithelial neoplasia

2013

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“…El 2,9% de la población estudiada tenía una infección asintomática y sin antecedentes de la patología, reforzando la evidencia epidemiológica de que este genotipo es endémico en el estado de Yucatán, México. Cuberos y cols, en un estudio de casos y controles, reportaron que 29,6% de los controles eran positivos al virus, siendo éste el único estudio además de los nuestros que han documentado la infección asintomática por este genotipo 25 . En el presente estudio, el virus se encontró solamente en sujetos con vida sexual; sin embargo, no hubo una asociación estadísticamente significativa (p > 0,05).…”

Section: Discussionunclassified

Epidemiología de la infección oral por VPH en sujetos jóvenes sanos

Cab-Sánchez

Hernández-Solís

Rueda-Gordillo

et al. 2017

Rev. chil. infectol.

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“…Described formally in 1965 in Native-Americans by Heck [1], this pathology is frequent in populations of 2-13 years of age, and its incidence is unequally distributed worldwide, affecting Native-Americans and indigenous populations the most [1][2][3][4][5][6]. There is no concrete evidence of affection of a particular male or female gender, as this varies with previous studies [7].…”

Section: Introductionmentioning

confidence: 99%

“…These lesions can be found in all of the extent of the oral mucosa epithelium, including lips, tongue and hard palate. The former being the most frequent site of lesions, specifically the lower lip [5]. Lesions tend to appear at an early age, usually before the age of five, and persist until the early teenage years.…”

Section: Introductionmentioning

confidence: 99%

Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels

Zavala-Garcia¹,

Briceño-Mena²,

Romero-Beltran³

et al. 2017

J immuno Biol

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Heck's disease, or Focal Epithelial Hyperplasia (FEH), caused by Human Papilloma Virus (HPV) subtypes 13 and mainly 32, is a rare and benign pathology of the oral mucosa; diagnosis is confirmed by PCR analysis. This is a common disease in the Mayan and other Native-American populations, most frequently between 2-13 years. Risk factors include lower income class, poor hygiene and genetic predisposition.This cross-sectional study aims to determine the prevalence of clinically compatible lesions of FEH in children from low, middle and high-income in 3 elementary schools in Yucatan, Mexico.Clinical evaluation was conducted and documented for later analysis by a dermatologist familiar with FEH. Samples were taken and HPV-13 was identified by PCR.The total of 186 subjects were analyzed from the low-income elementary school, with 41 subjects presenting FEH lesions and 76 presented HPV-13 upon PCR analysis. In the middle-income school, of the 144 subjects studied, 3 had FEH lesions and 8 presented HPV-13 upon PCR analysis. In the high-income elementary school, 96 students were studied, and none presented FEH lesions, however, 6 had HPV-13 positivity.FEH and HPV-13 prevalence were inversely proportional to socioeconomic status. Lacking an association to a particular gender or difference in the age groups studied.

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Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: A case-control study

Cited by 41 publications

References 34 publications

Human papillomavirus-associated oral intraepithelial neoplasia

Human papillomavirus-associated oral intraepithelial neoplasia

Epidemiología de la infección oral por VPH en sujetos jóvenes sanos

Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels

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