Molecular approaches to contraceptive development

Natraj, Usha

doi:10.1007/bf02704742

Cited by 3 publications

(1 citation statement)

References 82 publications

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“…Apart of the general interest in how the human endocrine systems operates, the mathematical modeling of testosterone regulation is pertaining to such important medical problems as treatment of reproductive failure, treatment of prostate cancer, development of oral contraceptives for men, [19]. Besides, alternations in GnRH pulsatile pattern are known to be related to obesity and aging.…”

Section: Introductionmentioning

confidence: 99%

Mathematical model of testosterone regulation by pulse-modulated feedback

Churilov

Medvedev

Shepeljavyi

2007

2007 IEEE International Conference on Control Applications

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A mathematical model of the pulse-modulated regulation of non-basal testosterone secretion in the male is introduced. The suggested model is of third order, reflecting the three most significant hormones in the regulation loop, but yet is shown to be capable of sustaining periodic solutions with one or two pulses of gonadotropin-releasing hormone (GnRH) in each period. Lack of stable periodic solutions is otherwise a main shortcoming of existing low-order hormone regulation models. The periodic mode with two GnRH pulses in the least period has not yet been described in medical literature but is supported by experimental data.

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Section: Introductionmentioning

confidence: 99%

Mathematical model of testosterone regulation by pulse-modulated feedback

Churilov

Medvedev

Shepeljavyi

2007

2007 IEEE International Conference on Control Applications

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Zuk�nftige Wege der ovariellen Stimulation

Griesinger

Schultze-Mosgau

Felberbaum

et al. 2003

Gyn�kologische Endokrinologie

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Vergleich der Eigenschaften von natürlichem und rekombinantem follikelstimulierendem Hormon (FSH). (Mod. nach [36]) Charakteristika Natürliches FSH Rekombinantes FSH Spezifische Aktivität FSH/mg Protein (I.E.) Etwa 150 Etwa 10.000 Proteingehalt/75 I.E. [mg] 370-750 5-11 Reinheit [%] <3 >99 Isoelektrischer Punkt (pH) 3,0-5,5 3,5-6,1 Zukünftige Wege der ovariellen Stimulationnon-peptide GnRH analogues are beginning to emerge which should allow oral administration and,therefore,may provide greater flexibility of dosing and increased patient acceptance.Other non-peptide agents with agonistic action at the FSH and LH receptor are currently being developed.For ovulation induction,aromatase inhibitors have recently gained attention.

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Fifty Years of “the Pill”: Risk Reduction and Discovery of Benefits Beyond Contraception, Reflections, and Forecast

Chadwick

Burkman

Tornesi³

et al. 2011

Toxicological Sciences

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Widely regarded as a revolutionary drug in its early years, "the pill" may be considered the first designer or lifestyle drug. Approximately 85% of women in the United States will use an oral contraceptive (OC) for an average of 5 years. Since the introduction of OCs in the 1960s, both health benefits and safety concerns have been attributed to their use. Widespread use of OC formulations by women throughout their reproductive life cycle gave rise to concerns about the effects of OCs on risk factors for cardiovascular disorders and cancer. In most instances, the noncontraceptive benefits of OCs outweigh the potential risks. As with many first in class drugs, lessons can be learned from its development and use. Indeed, "the pill" played a significant role in reshaping the regulatory process for new drugs during the second half of the 20th century. The birth control pill celebrates its 50th birthday this year, as women and men celebrate five decades of this revolutionary method of family planning. Recent scientific and technological advances in genomics, proteomics, new materials, and new drug delivery systems, along with a new understanding of reproductive biology, offer the promise of new, safe, and effective forms of contraception. In addition to the history of OC therapeutic advances and unintended side effects, the noncontraceptive health benefits that women experience beyond pregnancy prevention are discussed. This article summarizes a symposium presented at the 50th Anniversary of the Society of Toxicology National Meeting, held from 6 to 10 March 2011 in Washington, DC.

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Molecular approaches to contraceptive development

Cited by 3 publications

References 82 publications

Mathematical model of testosterone regulation by pulse-modulated feedback

Mathematical model of testosterone regulation by pulse-modulated feedback

Zuk�nftige Wege der ovariellen Stimulation

Fifty Years of “the Pill”: Risk Reduction and Discovery of Benefits Beyond Contraception, Reflections, and Forecast

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