Molecular aspects of alcoholic liver fibr

Kiseleva, Yana V; Zharikov, Yuri; Maslennikov, Roman; Pavlov, Chavdar S; Николенко, В.Н.

doi:10.14300/mnnc.2020.15070

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Прогрессирующие заболевания печени представляют собой серьезную проблему, от этого страдает более 1,5 млрд человек во всем мире [1]. Кроме того, прогрессирующее течение фиброза печени ведет к развитию цирротических изменений органа, что, по данным статистики, ежегодно служит причиной более 1,4 млн летальных исходов в мире [14].…”

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The relationship between the active cell mass index and complications of liver cirrhosis: ascites and hepatic encephalopathy

Zharikov,

Maslennikov,

Zharikova

et al. 2024

jour

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Changes in body composition, in particular sarcopenia and sarcopenic obesity, are complications of liver cirrhosis affected by unfavorable parent substances. The selection of diet and exercise for at least 8 weeks allows you to get the best results when taken by patients with cirrhosis of the liver. The correlate of motor activity in the bioimpedance analysis of the active fraction of the active cell mass in the lean mass of the human body. Aim of the study. To assess the relationship between increased cell mass and the severity of ascites and hepatic encephalopathy in liver cirrhosis. Material and methods. 46 patients with liver cirrhosis were examined. The component composition of the body is felt with the help of ABC-01 "Medass" devices (STC Medass, Russia). Ascites was assessed during the clinical examination, as well as the results of the examination of the abdominal cavity and retroperitoneal space. Diagnosis of hepatic encephalopathy impact test on the speed of cognitive reaction: "Number connection test". Results. A significant relationship was found between the proportion of active cell mass and the severity of ascites (r = –0.312, p-value = 0.034), indicating that a decrease in active cell mass is a prognostically unfavorable disease for the progression of ascites in patients with liver cirrhosis. Correlation analysis showed the presence of a negative correlation average strength between the values of the share of AKM in TMT and high body weight of PE: r = –0.229 (p value = 0.125), which requires research on studies between the values of the relationship between active cell mass and body weight. hepatic encephalopathy. Conclusion. Sensitive relationships have been found between active cell mass and the severity of liver cirrhosis. Determination of body composition products, in particular the absolute and relative indicators of active cell mass, in patients with liver cirrhosis can be of practical use in compiling promising mathematical models of prognosis.

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The relationship between the active cell mass index and complications of liver cirrhosis: ascites and hepatic encephalopathy

Zharikov,

Maslennikov,

Zharikova

et al. 2024

jour

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Сorrelation between somatotypes and body fat changes in patients with liver cirrhosis

Zharikov

Maslennikov

Gadzhiakhmedova

et al. 2023

Tihookeanskij medicinskij žurnal

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Objective. To evaluate the nature of changes in body fat composition in cirrhotic patients of various somatotypes.Materials and methods. The data of 46 cirrhotic patients and 20 volunteers were analyzed. Anthropometric examination was carried out according to methodological requirements with assessing the body composition of patients by means of bioimpedance analysis using ABC-01 Medass system (NTC Medass, Russia). Somatotypes were determined according to the Heath–Carter method. Ranks for the somatotype scale were assigned as endomorphy scores increased. Spearman rank correlation was used to identify the relationships between the variables. Differences between continuous variables were determined using the Mann–Whitney test. Statistical analysis was performed using Statistica 10 (StatSoft Inc., USA).Results. Child–Pugh scores for men and women were 9 (7.3–11.8) and 7 (6–9), respectively. Body fat percentage (BFP) of cirrhotic patients accounted for 27.7% (23.3–33) in men and 41.2% (33.6–46.3) in women. In healthy volunteers, the BFP was 21.9% (13.9–26.3) in men and 32.7% (29.3–41.6) in women. Assessment of the relationships between liver cirrhosis severity and body fat was characterized by a correlation coefficient of r = -0.47528 (p-value < 0.001). A significant negative correlation was determined between the liver cirrhosis severity according to Child–Pugh scores and somatotypes (r = -0.30536, p = 0.03905).Conclusion. The results of this study emphasize the correlation between somatotypes and changes in BFP in patients with liver cirrhosis of various degrees of severity. The sum of Child–Pugh scores and endomorphic indicators demonstrated the inverse relationship, which must be taken into account when developing mathematical models of the personalized prognosis of liver cirrhosis.

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Molecular aspects of alcoholic liver fibr

Abstract: 33. Loo T. W., Clarke D. M. Corrector VX-809 promotes interactions between cytoplasmic loop one and the first nucleotide-binding domain of CFTR.

Cited by 2 publications

References 37 publications

The relationship between the active cell mass index and complications of liver cirrhosis: ascites and hepatic encephalopathy

The relationship between the active cell mass index and complications of liver cirrhosis: ascites and hepatic encephalopathy

Сorrelation between somatotypes and body fat changes in patients with liver cirrhosis

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