Molecular Aspects of Exercise-induced Cardiac Remodeling

Bernardo, Bianca C.; McMullen, Julie R.

doi:10.1016/j.ccl.2016.06.002

Cited by 35 publications

(23 citation statements)

References 117 publications

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“…Physiological remodeling is normally characterized by coordinated CM growth and increased vascularity (71,72). This contrasts with pathological cardiac hypertrophy in which CM growth outpaces vascularization, leading to localized ischemia (73,74).…”

Section: Discussionmentioning

confidence: 99%

Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts

Lighthouse¹,

Burke²,

Velasquez³

et al. 2019

JCI Insight

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Section: Discussionmentioning

confidence: 99%

Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts

Lighthouse¹,

Burke²,

Velasquez³

et al. 2019

JCI Insight

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“…Different intensity of training may create different response of cardiac hypertrophy. In response to moderate training, cardiac hypertrophy occurs as an adaptive physiological response that is associated with normal or improved cardiac function [32, 33]. However, it is unavoided that endurance training have correlation with maladaptive responses in cardiac hypertrophy which is involving abnormal dynamic regulation of blood pressure, and histological rearrangement forming fibrotic tissue.…”

Section: Discussionmentioning

confidence: 99%

“…However in this study, the most marker of myocardial fibrosis returned to baseline after discontinuation of training. This suggests that the fibrosis is of the reactive phenotype, which is reversible after detraining [33, 34].…”

Section: Discussionmentioning

confidence: 99%

Cardiac hypertrophy is stimulated by altered training intensity and correlates with autophagy modulation in male Wistar rats

Gunadi

Tarawan

Setiawan

et al. 2019

BMC Sports Sci Med Rehabil

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Background: The mechanism for cardiac hypertrophy process that would be a benefit for improvement of cardiovascular endurance needed to be investigated throughly. Specific intensity of training may play a role for homeostasis process in cardiac during training. In the present study, we examine the effect of different intensity of treadmill training on cardiac hypertrophy process and autophagy related gene expression in male wistar rats. Methods: Three different intensities of treadmill training were conducted on 15 male wistar rats (Low Intensity: 10 m/ minute, Moderate Intensity: 20 m/minute, and High Intensity: 30 m/minute) compared to 5 sedentary rats as control. Training duration was 30 min per day, frequency was 5 days per week, during 8 weeks period. Heart weight and heart weight/body weight ratio were measured after the experiments. Left ventricle myocardium was taken for microscopic analysis with HE staining. mRNA was extracted from left ventricle myocardium for examining αMHC and autophagy related gene expression (PIK3CA, mTOR, LC3, p62) using semi quantitative PCR. Results: We observed that altered training intensity might stimulate cardiac hypertrophy process. MI and HI training increased heart weight and heart weight/body weight ratio. This finding is supported by microscopic result in which cardiac hypertrophy was found in MI and HI, with focal fibrosis in HI, and increased αMHC gene expression in MI (p < 0.05) and HI (p = 0.076). We also observed decreased PIK3CA (LI 0.8 fold, MI 0.9 fold), mTOR (LI 0.9 fold, MI 0.9 fold), LC3 (LI 0.9 fold, MI 0.8 fold, HI 0.8 fold), and p62 (LI 0.8 fold, MI 0.9 fold) compared to control. Interestingly, we found increased mTOR (HI 1.1 fold) and p62 (HI 1.1 fold) compared to control. Conclusion: Training with different intensity creates different cardiac hypertrophy process based on heart weight and heart weight/body weight ratio, microscopic examination and autophagy related gene expression.

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“…The cardioprotective effect of exercise occurs through a variety of adaptations such as healthy growing of cardiomyocytes and decreased fibrosis deposition in the heart [3]. At the cellular level, the improved cardiomyocyte contractility promoted by exercise training is particularly associated with improved Ca 2 + dynamics [24] which may be a result of reduced ROS production [9].…”

Section: Discussionmentioning

confidence: 99%

Exercise Training Protects Cardiomyocytes from Deleterious Effects of Palmitate

et al. 2017

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We investigated the effects of palmitate, a high saturated fat, on Ca, action potential and reactive oxygen species dynamics in cardiomyocytes from untrained and trained mice. Male mice were subjected to moderate intensity exercise training on a treadmill. Cardiomyocytes of untrained and trained mice were isolated, treated for 30 min with palmitate and intracellular calcium transient and action potential duration were recorded. Additionally, we assessed reactive oxygen species generation. Treatment of cardiomyocytes from untrained mice with palmitate induced a significant decrease in Ca transient magnitude by 34%. Exercise training did not change cardiomyocyte Ca dynamics in the control group. However, trained cardiomyocytes were protected from deleterious effects of palmitate. Action potential duration was not altered by palmitate in either untrained or trained cardiomyocytes. Moreover, palmitate treatment increased reactive oxygen species generation in both untrained and trained cardiomyocytes. Nevertheless, the levels of reactive oxygen species in trained cardiomyocytes treated with palmitate were still 27% lower than those seen at basal conditions in untrained cardiomyocytes. Taken together, these findings indicate that exercise training protects cardiomyocytes from deleterious effects of palmitate possibly by inhibiting exacerbated ROS production.

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Molecular Aspects of Exercise-induced Cardiac Remodeling

Cited by 35 publications

References 117 publications

Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts

Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts

Cardiac hypertrophy is stimulated by altered training intensity and correlates with autophagy modulation in male Wistar rats

Exercise Training Protects Cardiomyocytes from Deleterious Effects of Palmitate

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