Molecular Aspects of Hepatitis B Viral Infection and the Viral Carcinogenesis

Ryu, Wang Shick

doi:10.5483/bmbrep.2003.36.1.138

Cited by 17 publications

(6 citation statements)

References 44 publications

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“…It is recognized that HBV is one of the few human oncogenous viruses. [21] HCC incidence is higher in countries where hepatitis B is endemic. Addition of HDV infection seems to increase the risk of HCC development.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?

Abbas

Qureshi

Salehiniya

et al. 2012

Saudi J Gastroenterol

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Background/Aim:Hepatitis D virus (HDV) superinfection in patients with chronic hepatitis B leads to accelerated liver injury, early cirrhosis, and decompensation. It may be speculated that hepatocellular carcinoma (HCC) may differ in these patients from hepatitis B virus (HBV) monoinfection. The aim of this study was to compare clinical aspects of hepatocellular carcinoma in patients of hepatitis D with HBV monoinfection.Patients and Methods:A total of 92 consecutive HCC cases seropositive for antibody against HDV antigen (HDV group) were compared with 92 HBsAg-positive and anti-HDV-negative cases (HBV group).Results:The features including sex, body mass index, presence of ascites, serum biochemistry, gross tumor appearance, child class, barcelona cancer liver clinic and okuda stages were not significantly different between the 2 groups. Decreased liver size was noticed more in cases of HDV compared with HBV group where the liver size was normal or increased (P=0.000). HDV patients had lower platelets (P=0.053) and larger varices on endoscopy (P=0.004). Multifocal tumors and elevated alpha-fetoprotein level >1000 IU/mL were more common in HBV group (P=0.040 and P= 0.061). TNM classification showed more stage III-IV disease in HBV group (P=0.000).Conclusion:Decreased liver size and indirect evidence of more severe portal hypertension and earlier TNM stage compared with HBV monoinfection indicate that HDV infection causes HCC in a different way, possibly indirectly by inducing inflammation and cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?

Abbas

Qureshi

Salehiniya

et al. 2012

Saudi J Gastroenterol

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“…HBV may mediate HCC formation directly due to the viral inflammation process. But accumulating evidence shows that HBV-encoded regulatory proteins directly contribute to the HCC tumor progression [5]. HBV-encoded X protein (HBx), one of these regulatory proteins, has been reported to play the most significant role in this regulation [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Virus X Upregulates HuR Protein Level to Stabilize HER2 Expression in Hepatocellular Carcinoma Cells

Hung

Huang

Pan

et al. 2014

BioMed Research International

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Hepatitis B virus- (HBV-) associated hepatocellular carcinoma (HCC) is the most common type of liver cancer. However, the underlying mechanism of HCC tumorigenesis is very complicated and HBV-encoded X protein (HBx) has been reported to play the most important role in this process. Activation of downstream signal pathways of epidermal growth factor receptor (EGFR) family is known to mediate HBx-dependent HCC tumor progression. Interestingly, HER2 (also known as ErbB2/Neu/EGFR2) is frequently overexpressed in HBx-expressing HCC patients and is associated with their poor prognosis. However, it remains unclear whether and how HBx regulates HER2 expression. In this study, our data showed that HBx expression increased HER2 protein level via enhancing its mRNA stability. The induction of RNA-binding protein HuR expression by HBx mediated the HER2 mRNA stabilization. Finally, the upregulated HER2 expression promoted the migration ability of HBx-expressing HCC cells. These findings deciphered the molecular mechanism of HBx-mediated HER2 upregulation in HBV-associated HCC.

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“…Hepatitis B can potentially contribute to carcinogenesis through a number of mechanisms including disruption of cell signalling pathways, DNA repair mechanisms, and apoptotic pathways [5][6][7]. The role of occult hepatitis B in developing HCC is not clear, but the presence of occult hepatitis B in a large proportion of HBsAg negative persons with HCC [3] raises the potential for a role in carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Occult hepatitis B viral DNA in liver carcinomas from a region with a low prevalence of chronic hepatitis B infection

Kannangai¹,

Molmenti²,

Arrazola³

et al. 2004

Journal of Viral Hepatitis

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Occult hepatitis B is defined by the presence of hepatitis B viral (HBV) DNA in the serum or liver in persons lacking hepatitis B surface antigen (HBsAg) in the serum. A high prevalence of occult HBV has been reported in hepatocellular carcinoma (HCC) from Asia, but little information is available on the prevalence of occult HBV in HCC from regions with a low prevalence of typical chronic hepatitis B infection. In a retrospective study, 19 cases of primary liver cancer were investigated for the presence of occult HBV DNA by amplification of the surface, core, and X gene. In addition, HBV copy numbers were quantitated by real time polymerase chain reaction, genotyped, and samples tested for covalently closed circular HBV DNA, which is a marker of active viral replication. Occult HBV was found in three of 19 cases (16%). Genotyping was successful in two cases, both of which were genotype A. HBV DNA copy numbers were low, all less than 10 copies/microg liver DNA. No closed circular HBV DNA was detected. Thus, in this study occult HBV was of genotype A and was found in a low percentage of cases of HCC and was associated with low tissue HBV DNA copy numbers and no detectable evidence for viral replication.

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Molecular Aspects of Hepatitis B Viral Infection and the Viral Carcinogenesis

Cited by 17 publications

References 44 publications

Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?

Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?

Hepatitis B Virus X Upregulates HuR Protein Level to Stabilize HER2 Expression in Hepatocellular Carcinoma Cells

Occult hepatitis B viral DNA in liver carcinomas from a region with a low prevalence of chronic hepatitis B infection

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