Molecular Aspects of Immunoglobulin Expression by Human B Cell Leukemias and Lymphomas

Gordon, J

doi:10.1016/s0065-230x(08)60015-9

Cited by 27 publications

(13 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The difficulties encountered to date in this regard are well known (Nilsson and Klein, 1982;Gordon, 1984) and to an extent reflect our generally poor understanding of Bcell heterogeneity in vivo. These difficulties have been compounded, however, by the use of long-term cell lines as a source of BL cells for phenotypic analysis; it was therefore hoped that the present approach might provide a more accurate picture of BL cell identity.…”

Section: Discussionmentioning

confidence: 99%

Distinctions between endemic and sporadic forms of epstein‐barr virus‐positive burkitt's lymphoma

Rowe

Rooney

Rickinson

et al. 1985

Intl Journal of Cancer

108

View full text Add to dashboard Cite

Tumour cell lines were established in vitro from 16 cases of Epstein-Barr (EB) virus genome-positive Burkitt's lymphoma (BL), 7 of "endemic" origin (i.e. from holoendemic malarial areas of Africa and of New Guinea) and 9 of "sporadic" origin (i.e. from outside such high-incidence areas). All the BL cell lines thus established were monoclonal by immunoglobulin isotype expression and displayed a characteristic chromosomal translocation, t(8:14) or t(8:22), confirming their malignant origin. Clear differences observed between the individual BL cell lines appeared to be related to their endemic or sporadic status. All 7 endemic cell lines began growth as a carpet of single cells, often with small, loose clumps appearing in later passage. Whilst 3 lines of sporadic origin displayed a similar pattern to the above, the majority of sporadic lines grew as large, tight clumps of cells from the first passage onwards. These differences in growth pattern were reflected by differences in cell surface phenotype, as defined in indirect immunofluorescence tests using a panel of monoclonal antibodies (MAbs) specific for B-lineage-associated antigens. BL cell lines could be classified into 3 separate groups on the basis of their reactivity with 6 particular antibodies (MHM6, AC2, Ki-1, Ki-24, J5 and 38.13). All 7 endemic BL cell lines and 2 of the 3 sporadic BL cell lines which began growth as single cells showed a group-I cell-surface phenotype (MHM6, AC2, Ki-1, Ki-24 negative; J5, 38.13 positive) in early passage. In contrast, all 6 sporadic BL cell lines which began growth in large clumps displayed a distinct group-II phenotype (MHM6, AC2, Ki-1 positive/negative; Ki-24, J5, 38.13 positive); in later passage most of these sporadic lines progressed to a group-III phenotype (MHM6, AC2, Ki-1, Ki-24 positive; J5, 38.13 negative) without loss of those immunoglobulin and chromosomal markers identifying the cells' malignant origin. These clear differences between endemic BL cell lines on the one hand and the majority of sporadic BL cell lines on the other suggest that endemic BL arises from a more restricted range of progenitor B cells than does the sporadic form of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Distinctions between endemic and sporadic forms of epstein‐barr virus‐positive burkitt's lymphoma

Rowe

Rooney

Rickinson

et al. 1985

Intl Journal of Cancer

108

View full text Add to dashboard Cite

show abstract

“…Cells from some patients, but not others, enter S phase of the cell cycle after several days of culture with TPA (Godal et al, 1982). In some cases there is also secretion of considerable quantities of immunoglobulin (reviewed by Gordon, 1984). In all cases, irrespective of whether the cells enter S phase and/or secrete immunoglobulin, class II expression is markedly increased by culture of the cells with TPA (Totterman et al, 1981;Okamura et al, 1982;Guy et al, 1983aGuy et al, , 1983bGuy et al, 1986a, b).…”

Section: Mhc Class 11 Determinants As Allelic Markers Of B Cell Maligmentioning

confidence: 99%

“…Some findings suggest that this may be so. The TPA-induced differentiation of CLL cells which is characterized by morphological change, immunoglobulin secretion and cell cycle S phase entry (Gordon, 1984) is dependent on autologous helper T lymphocytes (Danersund et al, 1985). TPA-induced increases in class II expression are T cell independent (unpublished results (Guy et al, 1986a) and are apparently unaffected by treatment of the disease.…”

Section: Mhc Class 11 Determinants As Allelic Markers Of B Cell Maligmentioning

confidence: 99%

Expression of MHC class II antigens in human B-cell leukaemia and non-Hodgkin's lymphoma

Guy¹,

Krajewski²,

Dewar³

1986

Br J Cancer

View full text Add to dashboard Cite

Suggestions that human MHC class II antigens might be differentiation markers of leukaemic cells (Schlossman et al., 1976), and the demonstration that class II antigen expression is lost at the terminal stages of B cell differentiation, in both normal and malignant cells (Halper et al., 1978) date back almost a decade. These findings preceded the realization that MHC class II antigens are encoded by a large number of genes (Korman et al., 1985;. Recent detailed molecular studies of the structure of class II antigens , and their genes (Gustafsson et al., 1984), and the availability of monoclonal antibodies recognizing specific products of the different class II loci

show abstract

“…8, 8700Würzburg, F.R.G. 911 Lymphocytic Iymphoma B cells are thought tobe in a developmental stage closely related to immunocompetent, resting B cells [ 17]. Therefore we addressed the question how low grade NHL B eells ean respond to the two B-eeil aetivation pathways indueed either by eross-linking of the slg receptor or signals generated by IL-4.…”

Section: Jntroductionmentioning

confidence: 99%

Regulation of IL-4 responsiveness in lymphoma B cells

et al. 1991

View full text Add to dashboard Cite

Abstract-The responsiveness to IL-4 with and without costimulation with anti-IgM antibodies or phorbolester was studied in 35 cases of low grade non-Hodgkin Iymphoma by analyzing enhancement of CD23 and HLA dass li expression. The predominant phenotype responds directly to IL-4. Separate differentiation states can be distinguished according to coordinate or differential upregulation of CD23 and HLA dass II molecules by IL-4 alone, and differences in responsiveness to anti-IgM antibodies. A particular subgroup of B-lymphoma cells defines a separate stage of B-eeil differentiation. They fail to express high affinity binding sites for IL-4 and accordingly do not respond to IL-4-mediated signals. Cross-linking membrane lgM receptors or direct activation of protein kinase C via phorbolester induces IL-4 receptor expression and subsequent IL-4 reactivity.

show abstract

Molecular Aspects of Immunoglobulin Expression by Human B Cell Leukemias and Lymphomas

Cited by 27 publications

References 185 publications

Distinctions between endemic and sporadic forms of epstein‐barr virus‐positive burkitt's lymphoma

Distinctions between endemic and sporadic forms of epstein‐barr virus‐positive burkitt's lymphoma

Expression of MHC class II antigens in human B-cell leukaemia and non-Hodgkin's lymphoma

Regulation of IL-4 responsiveness in lymphoma B cells

Contact Info

Product

Resources

About