Molecular aspects on the interaction of phenosafranine to deoxyribonucleic acid: Model for intercalative drug–DNA binding

Das, Suman; Kumar, Gopinatha Suresh

doi:10.1016/j.molstruc.2007.02.016

Cited by 145 publications

(42 citation statements)

References 27 publications

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“…The observed changes in the CD spectra in the presence of AgNPs may be due to the deformity in base stacking and the helical structure of DNA. 43 Nevertheless the observed intrinsic B-DNA CD spectra does not specify any major structural transformation of B-form to other forms. From the changes in ellipticity shown in Figure 7d−f, we can conclude that changes in both right-handed ellipticity and base stacking induced by AgNPs are more pronounced in CT DNA compared to EC DNA and ML DNA.…”

Section: The Journal Of Physical Chemistry Bmentioning

confidence: 88%

Unraveling the Interaction of Silver Nanoparticles with Mammalian and Bacterial DNA

et al. 2016

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The focus of this study was to understand and unravel the interaction of silver nanoparticles (AgNPs) with different types of Deoxyribonucleic acid (DNA), mammalian and bacterial, having different base pair compositions. Binding of spherical silver nanoparticles (AgNPs) to Calf thymus (CT) DNA, Escherichia coli (EC) DNA and Micrococcus lysodeikticus (ML) DNA has been studied to gain insights into their mode of interaction and specificity. Interaction of AgNPs with synthetic DNA has also been carried out. On the basis of absorption, thermal melting, isothermal calorimetry and viscosity studies, we could establish the mode of binding and specificity of the synthesized silver nanoparticles with mammalian and bacterial DNA. Thermal melting (Tm) studies indicated a decrease in the Tm of all the DNAs, confirming the destabilization of DNA stacks on interaction with AgNPs. Comparative interaction studies with single stranded (ss) and double stranded (ds) DNAs further confirmed the specificity of the particles toward ds DNA. On the basis of the results we could confirm that the synthesized AgNPs could be used for selective detection of DNA through their DNA binding mechanism. In addition, the AgNPs-DNA complexes exhibited distinct differences in the SERS spectra making it an interesting SERS platform for identifying ds DNA. The optical and physical properties of AgNPs help in differentiating the DNAs of different base pair compositions through their binding affinity and specificity.

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Section: The Journal Of Physical Chemistry Bmentioning

confidence: 88%

Unraveling the Interaction of Silver Nanoparticles with Mammalian and Bacterial DNA

et al. 2016

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“…13 Helix Melting Experiments. A helix melting study was performed using the same spectrophotometer equipped with the Peltier-controlled TMSPC-8 model accessory (Shimadzu Corp., Japan).…”

Section: ■ Materials and Experimental Methodsmentioning

confidence: 99%

Deciphering the Positional Influence of the Hydroxyl Group in the Cinnamoyl Part of 3-Hydroxy Flavonoids for Structural Modification and Their Interaction with the Protonated and B Form of Calf Thymus DNA Using Spectroscopic and Molecular Modeling Studies

et al. 2015

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Studies on the interaction of naturally occurring flavonoids with different polymorphic forms of nucleic acid are helpful for understanding the molecular aspects of binding mode and providing direction for the use and design of new efficient therapeutic agents. However, much less information is available on the interactions of these compounds with different polymorphic forms of DNA at the molecular level. In this report we investigated the interaction of two widely abundant dietary flavonoids quercetin (Q) and morin (M) with calf thymus (CT) DNA. Spectrophotometric, spectropolarimetric, viscosity measurement, and molecular docking simulation methods are used as tools to delineate the binding mode and probable location of the flavonoids and their effects on the stability and conformation of DNA. It is observed that in the presence of the protonated form of DNA the dual fluorescence of Q and M resulting from the excited-state intramolecular proton transfer (ESIPT) is modified significantly. Structural analysis showed Q and M binds weakly to the B form (groove binding) compared to the protonated form of CT DNA (electrostatic interaction). In both cases, Q binds strongly to both forms of DNA compared to M.

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“…A JASCO J815 spectropolarimeter (Jasco International Co. Ltd., Tokyo, Japan) equipped with a Jasco temperature controller (model PFD 425 L/15) was used for all circular dichroic measurements at 20 ± 0.5°C as reported earlier [22][23][24]33,34]. A rectangular strain free quartz cell of 1 cm path length was used.…”

Section: Spectropolarimetric Studiesmentioning

confidence: 99%

Biophysical studies on the base specificity and energetics of the DNA interaction of photoactive dye thionine: Spectroscopic and calorimetric approach

Paul

Hossain

Yadav

et al. 2010

Biophysical Chemistry

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Molecular aspects on the interaction of phenosafranine to deoxyribonucleic acid: Model for intercalative drug–DNA binding

Cited by 145 publications

References 27 publications

Unraveling the Interaction of Silver Nanoparticles with Mammalian and Bacterial DNA

Unraveling the Interaction of Silver Nanoparticles with Mammalian and Bacterial DNA

Deciphering the Positional Influence of the Hydroxyl Group in the Cinnamoyl Part of 3-Hydroxy Flavonoids for Structural Modification and Their Interaction with the Protonated and B Form of Calf Thymus DNA Using Spectroscopic and Molecular Modeling Studies

Biophysical studies on the base specificity and energetics of the DNA interaction of photoactive dye thionine: Spectroscopic and calorimetric approach

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