Molecular-based nonlinear viscoelastic chemomechanical model incorporating thermal denaturation kinetics of collagen fibrous biomaterials

Młyniec, Andrzej; Tomaszewski, Krzysztof A.; Spiesz, Ewa M.; Uhl, Tadeusz

doi:10.1016/j.polymdegradstab.2015.05.005

Cited by 18 publications

(11 citation statements)

References 56 publications

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“…Such a model could, in the future, substitute live human tissue samples which are currently the main source of test material for AT biomechanical studies. 22,23 Moreover, such information is mandatory to develop more advanced methods of selective stretching of the GM, GL, and SOL for treatment their injuries. 3 Our observations on the prevalence of AT torsion types were similar to previous studies.…”

Section: T a B L Ementioning

confidence: 99%

“…The type of AT torsion alters the biomechanical properties of the tendon and may be connected with specific pathophysiologic mechanisms of various tendinopathies. 4 In recent years, studies concerning the molecular structure of collagen fibers, 22,23 which are the main constituents of the AT, have demonstrated the possibility of creating a computer model of the AT as basis for further chemomechanical modeling. The morphometric data describing the anatomical properties of the whole AT, as well as its particular subtendons, obtained by authors of this study, are crucial for constructing an accurate virtual model of the AT in the near future.…”

Section: Perspectivesmentioning

confidence: 99%

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The twisted structure of the Achilles tendon unraveled: A detailed quantitative and qualitative anatomical investigation

Pękala

Henry

Ochała

et al. 2017

Scandinavian Med Sci Sports

128

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The Achilles tendon (AT) consists of fibers originating from the soleus muscle (SOL), which lies deep, and the medial (GM) and lateral (GL) heads of the gastrocnemius muscle, which lie superficial. As the fibers descend toward the insertion of the AT, the individual subtendons twist around each other. The aim of this study was to investigate the twisted structure of the AT and its individual subtendons. Specimens of the AT, with preserved calcaneal bone and a fragment of the triceps surae muscle, were obtained from 53 fresh-frozen, male cadavers (n=106 lower limbs). The angle of torsion of each of the AT's subtendons was measured using a specially designed and 3D-printed tool. The mean distance between the most distal fibers of the triceps surae muscle and the superior border of the calcaneal bone was 60.77±14.15 mm. The largest component of the AT at the level of its insertion into the calcaneal bone is the subtendon from the GL (44.43%), followed by the subtendon from SOL (27.89%), and the subtendon from GM (27.68%). The fibers originating from the GM rotate on average 28.17±15.15°, while the fibers originating from the GL and SOL twist 135.98±33.58° and 128.58±29.63°, respectively. The torsion of superficial fibers (GM) comprising the AT is significantly lower than that of deeper fibers (GL and SOL). The cross-sectional area of the AT is smaller at the level of the musculo-tendinous junction than at the level of its insertion. This study illustrates the three types of the AT with differently twisting subtendons, as well as a generalized model of the AT. Types of AT torsion may potentially alter the biomechanical properties of the tendon, thus possibly influencing the pathophysiologic mechanisms leading to the development of various tendinopathies.

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Section: T a B L Ementioning

confidence: 99%

Section: Perspectivesmentioning

confidence: 99%

The twisted structure of the Achilles tendon unraveled: A detailed quantitative and qualitative anatomical investigation

Pękala

Henry

Ochała

et al. 2017

Scandinavian Med Sci Sports

128

View full text Add to dashboard Cite

show abstract

“…Further, no gradual transition zone between fascicles and interfascicular matrix was observed, but rather a sharp transition between the zones was seen. This certainly has consequences for the mechanical behaviour of tendons and is important for prescribing proper boundary conditions for modelling tendons mechanical behaviour [64] , [65] , [66] .…”

Section: Discussionmentioning

confidence: 99%

Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM)

et al. 2018

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“…Alterations of collagen properties can therefore affect the mechanical properties of bone and increase fracture susceptibility. Numerous studies suggest that part of the large variation in bone strength may be related to differences in the quality of the collagenous matrix, including the nature and extent of its posttranslational modifications [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Denaturation processes of collagen from cow bones as a function of temperature

et al. 2018

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The thermal stability of collagen is of great interest for the scientific communities both of medicine and archaeology. In medicine, the interest is focused to the reconstruction and repair of bone and cartilage, given the frequency and importance of pathological situations. In contrast, in archaeology the interest is focused to infer from buried and/or burned bones the behavior and habits of people who once inhabited archaeological sites. In bones from cow ribs, the biodegradation of collagen by denaturation of albumin and haemoglobin proteins, the loss of water and the loss of crystallization water during warming up to around 450 K, have been studied. In addition, from an easy-to-handle mathematical viscoelastic procedure, it was determined that the conformational changes from the collagenic triple helix towards the random coil are made through the viscous movement of fibrils, invoking an activation energy of (127 ± 8) kJ/mol. In the present work, the thermal stability of type I collagen from cow bones, either femur and rib, was studied in the temperature range from 250 K up to 670 K by means of dynamic mechanical analysis, scanning electron microscopy and infrared absorption spectroscopy. In fact, this temperature range is wider than the previous explored ones. Several stages of denaturation were found in the temperature range from 320 K up to 670 K, including also the transition from the triple helix (TH) towards the random coil (RC) of the collagen fibrils. The temperature for the TH  RC transition was approximately the same for all the kinds of bones, but the intensity of the relaxation processes depended upon the kind of bone. The differences between the denaturation processes in the femur and rib are highlighted and the physical-chemical mechanisms controlling the denaturation processes are discussed. In fact, different behaviours of the mesostructure were found between the cortical parts of bones from ribs and femurs. In addition, the cancellous parts from ribs bone exhibits the survival of organic compounds even at temperatures as higher as 673 K. The results from the present work are crucial both for the tissue engineering, focused to bone replacement and pathologic treatments, and for the archaeology, for the study of identification of buried and/or burned bones in archaeological sites.

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Molecular-based nonlinear viscoelastic chemomechanical model incorporating thermal denaturation kinetics of collagen fibrous biomaterials

Cited by 18 publications

References 56 publications

The twisted structure of the Achilles tendon unraveled: A detailed quantitative and qualitative anatomical investigation

The twisted structure of the Achilles tendon unraveled: A detailed quantitative and qualitative anatomical investigation

Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM)

Denaturation processes of collagen from cow bones as a function of temperature

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