Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress

Viña, José; Lloret, Ana; Orti, R.; Alonso, Dolores

doi:10.1016/j.mam.2004.02.013

Cited by 118 publications

(63 citation statements)

References 27 publications

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“…Mitochondrial dysfunction and ROS production have been implicated in many, if not all, neurodegenerative processes, and also in association with changes in local blood flow, such as stroke [28][29][30][31][32][33][34][35][36]. The use of antioxidant agents to prevent neurodegeneration has been widely described [32,33,[37][38][39][40][41][42].…”

Section: Identifying Treatments To Reduce Neurodegenerative Diseasementioning

confidence: 99%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

201

188

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Free radical formation in the cochlea plays a key role in the development of noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant formation of both reactive oxygen species and reactive nitrogen species 7-10 days following noise exposure. Reduction in cochlear blood flow as a result of free radical formation has also been described. Here we report that the antioxidant agents, vitamins A, C, and E, act in synergy with magnesium to effectively prevent noise-induced trauma. Neither the antioxidant agents nor magnesium reliably reduced NIHL or sensory cell death with the doses we used when these agents were delivered alone. In combination, however, they were highly effective in reducing both hearing loss and cell death even with treatment initiated just one hour prior to noise exposure. This study supports roles for both free radical formation and noise-induced vasoconstriction in the onset and progression of NIHL. Identification of this safe and effective antioxidant intervention that attenuates NIHL provides a compelling rationale for human trials in which free radical scavengers are used to eliminate this single major cause of acquired hearing loss. Keywords cochlea; free radical; noise; hearing; antioxidant; vasodilation Mechanical destruction of cells in the organ of Corti was once assumed to be the primary cause of noise-induced hearing loss (NIHL) [1][2][3][4][5][6][7][8], with perhaps some effect of reduced blood flow to the inner ear [9][10][11][12][13][14][15][16][17][18]. We now know that another key factor is intense metabolic activity that results in production of excess free radicals [19][20][21][22][23] and lipid peroxidation products [24]. Noise-induced production of reactive oxygen species (ROS) in the cochlea has now been well characterized, and several recent reviews are available [25][26][27]. Mitochodrial dysfunction and ROS production have been implicated in numerous neurodegenerative syndromes and diseases [28-34, see 35,36]. The use of antioxidant agents holds significant therapeutic promise for many neurodegenerative processes [32,33,[37][38][39][40][41][42], and there is some suggestion that Correspondence to: C. G. Le Prell, Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA. Tel: +1-734-763-5104; fax +1-734-764-0014. E-mail address: colleeng@umich.edu. Disclosure. Dr. Miller is a founding member and Chairman of the Board of Directors at OtoMedicine, Inc., a company that has an option to license the intellectual property described in this report. Dr. Le Prell is a paid consultant to OtoMedicine, Inc. Drs. Miller and Le Prell have disclosed these relationships to the Medical School Conflict of Interest Board at the University of Michigan; conflict management plans including semi-annual review by the Board are in place.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publicatio...

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Section: Identifying Treatments To Reduce Neurodegenerative Diseasementioning

confidence: 99%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

201

188

View full text Add to dashboard Cite

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“…There is a negative correlation between plasmatic levels of antioxidants, mainly vitamin E, and incidence of cardiovascular diseases and some types of cancer (see Fusco et al, 2007 andHercberg et al, 2009). This correlation is also present for fruits and vegetables intake (Genkinger et al, 2004) and flavonoids and polyphenols (Manach et al, 2005) and for other age-related diseases such as Alzheimer disease (Viña et al, 2004) or diabetes (Czernichow et al, 2006).…”

Section: Antioxidative Therapiesmentioning

confidence: 83%

Pharmacological Approaches to Improve Ageing

Camello¹,

Camello-Almaraz²,

Pozo³

2012

Pharmacology

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“…This suggest that the aerial part of S. cryptantha may contain some considerable amount of Nitrogen [79] and a moderate composition of alkaloidal compounds [80]. Plants products contains a wide variety of bioactive molecules, such as tarpenoids, phenolic, carotenoids, vitamins and other micronutrients which were reported to play vital roles as health protecting agents [81]. Hlila, Mosbah [60] tested the AChE inhibitory activity of root extracts of S. arenaria and characterized nine bioactive compounds in different solvent fractions, including p-coumaric acid, N-propyl gallate, myricetin and methyl-4-hydroxybenzoate.…”

Section: Discussionmentioning

confidence: 99%

Medicinal Plants Anti-cholinesterase Activity and the Potential for Alzheimer’s Disease Treatment

Usman¹

2017

JDMP

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Abstract:Alzheimer's disease (AD) is a slow and progressive neurodegenerative disease, leading to a breakdown in memory preservation and absence of cognitive reasoning and language skills. It is the most popular neurodegenerative disease worldwide, with nearly 20 million new incidences recorded every year. The enzymes, acetyl cholinesterase (AChE) and butyryl-cholinesterase (BChE) play important roles in the cholinergic deficit through enhanced degradation of the neurotransmitter, acetylcholine (ACh). In most cases, to improve neurotransmission and to alleviate cholinergic deficit, the focus is mainly on acetyl cholinesterase (AChE) and butyl cholinesterase (BCh). Currently, drugs for the treatment of AD (Rivastigmine, galanthamine, donepezil and Memantine) targets the later stages and implicated in the progression of the disease. Acetyl cholinesterase enzyme (AChE) is especially an attractive target for the rational drug design and for the discovery of mechanism based inhibitors; this is because of its role in the hydrolysis of neurotransmitter, acetylcholine. Many plants serve as potential source of AChE and BChE inhibitors, and useful compounds that could provide templates for the development of drugs for the treatment of AD. This paper provides a review of several medicinal plants tested for anti-AChE and or BChE, many of which contains promising bioactive compounds as potential anti-cholinesterase that could serve as candidates for the development of drugs to treat AD.

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Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress

Cited by 118 publications

References 27 publications

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Pharmacological Approaches to Improve Ageing

Medicinal Plants Anti-cholinesterase Activity and the Potential for Alzheimer’s Disease Treatment

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