Molecular basis and mechanism of action of Albizia julibrissin in depression treatment and clinical application of its formulae

Huang, Bishan; Wu, Yingyao; Li, Chan; Tang, Qinglian; Zhang, Yuanwei

doi:10.1016/j.chmed.2022.10.004

Cited by 10 publications

(3 citation statements)

References 74 publications

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“…Accumulating evidence has shown that the lack of monoamine neurotransmitters, such as Dopamine (DA), Norepinephrine (NE) and 5-hydroxytryptamine (5-HT), in the brain is associated with depression. [30] Therefore, the level of monoamine neurotransmitters in the brain of CUMS rats was detected to evaluate the ameliorative effects of BS and VBS. As shown in Figure 1G, 1H, and 1I, compared with the control group, DA, NE, and 5-HT in the brains of model rats were markedly reduced (P < 0.01).…”

Section: Bs and Vbs Ameliorated The Level Of Monoamine Neurotransmitt...mentioning

confidence: 99%

Two Omics Methods Expose Anti‐Depression Mechanism of Raw and Vinegar‐Baked Bupleurum Scorzonerifolium Willd

Qu,

Zheng,

et al. 2024

Chemistry & Biodiversity

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Bupleurum scorzonerifolium willd. (BS) and its vinegar‐baked product (VBS) has been frequently utilized for depression management in clinical Chinese medicine. This paper aims to elucidate the antidepressant mechanism of BS and VBS from the perspectives of metabonomics and gut microbiota. A rat model of depression was established by CUMS combined with feeding alone to evaluate the antidepressant effects of BS and VBS. UPLC‐Q‐TOF‐MS/MS‐based metabolomics and 16S rRNA sequencing of rat feces were applied and the correlation of differential metabolic markers and intestinal floras was analyzed. The result revealed that BS and VBS significantly improved depression‐like behaviors and the levels of monoamine neurotransmitters in CUMS rats. There were 27 differential endogenous metabolites between CUMS and normal rats, which were involved in 8 metabolic pathways. Whereas, BS and VBS could regulate 18 and 20 metabolites respectively, wherein fifteen of them were shared metabolites. On the genus level, BS and VBS could regulate twenty‐five kinds of intestinal floras in CUMS rats, that is, they increased the abundance of beneficial bacteria and decreased the abundance of harmful bacteria. In conclusion, both BS and VBS exert excellent antidepressant effects by regulating various metabolic pathways and ameliorating intestinal microflora dysfunction.

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Section: Bs and Vbs Ameliorated The Level Of Monoamine Neurotransmitt...mentioning

confidence: 99%

Two Omics Methods Expose Anti‐Depression Mechanism of Raw and Vinegar‐Baked Bupleurum Scorzonerifolium Willd

Qu,

Zheng,

et al. 2024

Chemistry & Biodiversity

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“…Indigofera atropurpurea flowers are used for diarrhea and dysentery [ 15 ]. Similarly, Albizia julibrissin is used in Chinese medicine to treat ulcers, boils, bruises, fractures, insomnia, anxiety, and hemorrhoids [ 13 , 16 ]. The reported pharmacological properties of A. julibrissin include antitumor, antidepressant, antioxidant, and immunomodulatory activities [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Green solvent-based extraction of three Fabaceae species: A potential antioxidant, anti-diabetic, and anti-leishmanial agents

Fatima,

Safdar,

Akhtar

et al. 2024

Heliyon

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“…The bioactive phytochemicals present in Hehuanhua include triterpenoids, flavonoids, phenols, and alkaloids (Lu et al, 2023). The flavonoids, in particular, are associated with many different pharmacological activities which may influence mental health/ mood including anti-inflammatory, antidepressant, anxiolytic, as well as others like anti-obesity, anti-neoplastic and antiosteoporosis (Huang et al, 2023;Lu et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Impact of Baizhu, Daqingye, and Hehuanhua extracts on the human gut microbiome

Lemons,

Narrowe,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionIn traditional Chinese medicine, the rhizome of Atractylodes macrocephala (Baizhu), the leaves of Isatis indigotica (Daqingye), and the flowers of Albizia julibrissin (Hehuanhua) have been used to treat gastrointestinal illnesses, epidemics, and mental health issues. Modern researchers are now exploring the underlying mechanisms responsible for their efficacy. Previous studies often focused on the impact of purified chemicals or mixed extracts from these plants on cells in tissue culture or in rodent models.MethodsAs modulation of the human gut microbiome has been linked to host health status both within the gastrointestinal tract and in distant tissues, the effects of lipid-free ethanol extracts of Baizhu, Daqingye, and Hehuanhua on the human adult gut microbiome were assessed using Systemic Intestinal Fermentation Research (SIFR®) technology (n=6).Results and discussionBaizhu and Daqingye extracts similarly impacted microbial community structure and function, with the extent of effects being more pronounced for Baizhu. These effects included decreases in the Bacteroidetes phylum and increases in health-related Bifidobacterium spp. and short chain fatty acids which may contribute to Baizhu’s efficacy against gastrointestinal ailments. The changes upon Hehuanhua treatment were larger and included increases in multiple bacterial species, including Agathobaculum butyriciproducens, Adlercreutzia equolifaciens, and Gordonibacter pamelaeae, known to produce secondary metabolites beneficial to mental health. In addition, many of the changes induced by Hehuanhua correlated with a rise in Enterobacteriaceae spp., which may make the tested dose of this herb contraindicated for some individuals. Overall, there is some evidence to suggest that the palliative effect of these herbs may be mediated, in part, by their impact on the gut microbiome, but more research is needed to elucidate the exact mechanisms.

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Molecular basis and mechanism of action of Albizia julibrissin in depression treatment and clinical application of its formulae

Cited by 10 publications

References 74 publications

Two Omics Methods Expose Anti‐Depression Mechanism of Raw and Vinegar‐Baked Bupleurum Scorzonerifolium Willd

Two Omics Methods Expose Anti‐Depression Mechanism of Raw and Vinegar‐Baked Bupleurum Scorzonerifolium Willd

Green solvent-based extraction of three Fabaceae species: A potential antioxidant, anti-diabetic, and anti-leishmanial agents

Impact of Baizhu, Daqingye, and Hehuanhua extracts on the human gut microbiome

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