2023
DOI: 10.1016/j.celrep.2023.112172
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Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

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Cited by 15 publications
(24 citation statements)
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“…Therefore, rigidifying the regulatory motif likely explains the molecular basis for how it prevents kinase activity. The nanobody interface is distinct from the predicted Gbg interface (Rathinaswamy et al, 2023) and the experimentally resolved Ras interface (Pacold et al, 2000), explaining why it can still be membrane recruited by these stimuli.…”
Section: Molecular Mechanism Of Nanobody Inhibition Of P110gmentioning
confidence: 83%
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“…Therefore, rigidifying the regulatory motif likely explains the molecular basis for how it prevents kinase activity. The nanobody interface is distinct from the predicted Gbg interface (Rathinaswamy et al, 2023) and the experimentally resolved Ras interface (Pacold et al, 2000), explaining why it can still be membrane recruited by these stimuli.…”
Section: Molecular Mechanism Of Nanobody Inhibition Of P110gmentioning
confidence: 83%
“…The p110g-p84 complex forms a more dynamic complex compared to p110g-p101 (Rathinaswamy et al, 2023;Shymanets et al, 2013), however, no clear unique regulatory role of this difference in dynamics has been identified.…”
Section: Introductionmentioning
confidence: 99%
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