Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla

Inui, Shigeki; Itami, Satoshi

doi:10.1016/j.jdermsci.2010.10.015

Cited by 154 publications

(132 citation statements)

References 54 publications

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“…22 The active androgen dihydrotestosterone (DHT) is thought to play the basic role in the disorder, and increased sensitivity to this hormone at the hair follicle level is believed to cause hair loss by leading to follicular miniaturization. 8,9 AGA not being observed in males with 5a-reductase deficiency, an autosomal recessive genetic disorder, proves that DHT is the androgen metabolite actively involved in the development of male pattern hair loss. 22 Following the demonstration of the role played by androgens in the etiology of alopecia, various studies investigated AGA in combination with other diseases in which androgens are known to be involved and examined whether or not AGA is an early marker of these diseases.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6][7] Androgenetic alopecia (AGA), otherwise known as male pattern baldness, is a disorder characterized by follicular miniaturization resulting from increased sensitivity at the follicular level to dihydrotestosterone, a metabolite of testosterone. 8,9 Patients typically present with progressive hair thinning in the area affected, followed by hair loss. 10 The disorder affects nearly 50% of men in their lifetimes, and is more common in men with specific polymorphisms in their androgen receptor genes.…”

Section: Introductionmentioning

confidence: 99%

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The association of urolithiasis and androgenetic alopecia

et al. 2015

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Objectives: The objective of this study is to investigate whether patients with androgenetic alopecia were at risk in terms of urinary system stone disease. Patients and methods: Patients with no baldness (Hamilton-Norwood Scala [HNS] stage I) were categorized as Group I, those with hair loss in the frontal region (HNS stages II, III, IIIa, and IVa) as Group II, those with hair loss in the vertex region (HNS stage III-vertex, V) as Group III and those with hair loss in both vertex and frontal regions (HNS stages IV, Va, VI, and VII) as Group IV. Patients in all groups were compared in terms of presence of stone, and the presence of any association between alopecia and urolithiasis, with common etiological risk factors, was investigated. Results: Three hundred and two male patients were included in the study. The presence of urolithiasis was detected in 28.9% of patients in Group I; 26.5% of Group II; 36.9% of Group III; and 44.4% of Group IV (p ¼ 0.085). Among patients aged under 60, urinary stone disease was detected in 30.8% of patients in Group I; 26.4% of Group II; 41.2% of Group III; and 53.8% of Group IV (p ¼ 0.001). In patients aged over 60, urolithiasis was detected in 12.5% of patients in Group I; 26.9% of Group II; 32.2% of Group III; and 37.8% of Group IV (p ¼ 0.371). Conclusions: We determined a significant correlation between vertex pattern and total alopecia with urolithiasis in patients younger than 60 years old.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association of urolithiasis and androgenetic alopecia

et al. 2015

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“…Follicles from frontal and parietal areas of the human scalp are considered to be androgen-sensitive. There are also two more types of hair follicles: androgen-independent hair follicles, such as eyelashes, and androgen-dependent pigmented terminal hair follicles, such as beard [26,29,30]. Why do hair follicles have different sensitivity to androgens is still open question.…”

Section: Hair Follicle-related Signaling Pathways In Androgenic Alopeciamentioning

confidence: 99%

“…The changes in molecular signaling which follow the dermal papillae burst in balding scalp of a person with AGA result in suppressed growth of hair keratinocytes derived from DP cells [29]. Dermal papilla in developed hair follicle in anagen is surrounded by a proliferative zone within the hair bulb named matrix.…”

Section: Dermal Papilla-specific Signaling Pathwaysmentioning

confidence: 99%

Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

Nesterova¹,

Yuryev²

2017

Hair and Scalp Disorders

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Signaling pathways that control coordination of hair follicle cells genetic program are the convenient model for explaining the hierarchy of intercellular interactions governing cyclic growth of hair. This chapter describes models of molecular signaling pathways specific to dermal papilla cells from balding human scalp in hair follicle cycle. These models include already published data, as well as information inferred from pathway analysis of microarray data and protein-protein interaction database. Interplay of androgenic-alopecia-related signaling pathways FGF, TGFB, BMP, and WNT, as well as cyclin-dependent kinases signaling, is shown.

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“…In mature hair follicles, TGF-β1 mRNA is expressed in the inner hair root sheath, TGF-β2 mRNA is expressed at the end of the epithelium, while TGF-β3 in the neighboring district of the outer root sheath (Inui and Itami, 2011). Recent studies have found that expression of TGF-β1 in hair follicle cells have relations with epidermal repair (Liang et al, 2012).…”

Section: Transforming Growth Factor-β (Tgf-β)mentioning

confidence: 99%

Progress in Relevant Growth Factors Promoting the Growth of Hair Follicle

Valerie¹

2012

American Journal of Animal and Veterinary Sciences

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Abstract:Hair is a protective appendage on the body that is considered accessory structure of the integument. Hair follicle development takes place during fetal skin development and relies on tightly regulated ectodermal-mesodermal interactions. The morphological changes of the hair cycle have been very clear that hair morphogenesis and epidermal development are orchestrated by an array of growth factors. In this review, we summarize the major growth factors involved in promoting growth of hair follicles.

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Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla

Cited by 154 publications

References 54 publications

The association of urolithiasis and androgenetic alopecia

The association of urolithiasis and androgenetic alopecia

Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

Progress in Relevant Growth Factors Promoting the Growth of Hair Follicle

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