2015
DOI: 10.7603/s40730-015-0005-1
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Molecular Basis of Drug Interactions of Methotrexate, Cyclophosphamide and 5-Fluorouracil as Chemotherapeutic Agents in Cancer

Abstract: Abstract-At present, chemotherapy is one of the principal methods of treatment of cancer. For many years, chemotherapy is possibly the only way to control cancers that do not respond to either surgery or radiation. To date a good number of chemotherapeutic drugs have been developed which are effective in the treatment of human cancers. But, A few drugs have been known to be safe and promising. The most widely used chemotherapeutic drugs include methotrexate, cyclophosphamide, 5-fluorouracil etc. In this review… Show more

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Cited by 16 publications
(13 citation statements)
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References 45 publications
(40 reference statements)
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“…On the other hand, MTX induces apoptosis by activation of caspase‐3 . Contrary, stem cells are capable of reducing apoptosis as compared with the MTX group.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, MTX induces apoptosis by activation of caspase‐3 . Contrary, stem cells are capable of reducing apoptosis as compared with the MTX group.…”
Section: Discussionmentioning
confidence: 99%
“…The rationale of such different therapeutic approach might reside in the complex interactions between TP53 mutations, BRAF mutations and sensitivity to MTX. MTX inhibits the synthesis of DNA, RNA, thymidylates and proteins because it is a potent inhibitor of the dihydrofolate reductase (DHFR) enzyme, which converts dihydrofolate to tetrahydrofolate (THF) [ 62 ]. TP53 mutations induce an increase of E2F1 and are associated with DHFR gene amplification to start the invasion and metastasis process [ 63 ].…”
Section: Resultsmentioning
confidence: 99%
“…One major pathway of classical apoptosis is the receptormediated pathway or the extrinsic pathway. Another major pathway for the initiation of apoptosis is the mitochondrial pathway or the intrinsic pathway [25,26]. Both of these pathways are linked and involve caspases.…”
Section: Mechanism Of Action Of Artemisininmentioning
confidence: 99%