Molecular Basis of Health and Disease

Das, Undurti N.

doi:10.1007/978-94-007-0495-4

Cited by 62 publications

(106 citation statements)

References 566 publications

Supporting

Mentioning

105

Contrasting

Order By: Relevance

“…LA, GLA, DGLA, AA, ALA, EPA, and DHA also are called PUFAs. AA, EPA, and DHA (AA is an u-6 fatty acid, whereas both EPA and DHA are u-3 fatty acids) are essential for normal development and growth of brain and memory [41][42][43][44][45].…”

Section: Diffusion Tensor Imaging Magnetic Resonance Imaging and Autismmentioning

confidence: 99%

Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids

Das

2013

Nutrition

Self Cite

View full text Add to dashboard Cite

Section: Diffusion Tensor Imaging Magnetic Resonance Imaging and Autismmentioning

confidence: 99%

Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids

Das

2013

Nutrition

Self Cite

View full text Add to dashboard Cite

“…AA forms precursor not only to PGE 2 but also to an antiinflammatory compound lipoxin A 4 (LXA 4 ) [43,146,147]. LXA 4 exhibited inhibitory effects on edema, neutrophil infiltration, and vascular permeability, expressions of interleukin (IL)-1, IL-6, and IL-8 mRNA, DNA-binding activity of nuclear factor-kappaB (NF-kappaB), and blocked NF-kappaB reporter activities and nuclear translocations of NF-kappaB p65.…”

Section: Differential Action Of Pufas On Normal and Tumor Cellsmentioning

confidence: 99%

“…In general, the terms EFAs and PUFAs are used by many interchangeably but it should be noted that all EFAs are PUFAs but all PUFAs are not EFAs. PUFAs give rise to various prostaglandins (PGs), leukotrienes (LTs), thromboxanes (TXs), lipoxins, resolvins, protectins, and maresins that have important roles both in physiology and pathology of various diseases [36][37][38][39][40][41][42][43][44][45][46][47][48][49].…”

Section: Metabolism Of Essential Fatty Acidsmentioning

confidence: 99%

Essential fatty acids and their metabolites as modulators of stem cell biology with reference to inflammation, cancer, and metastasis

Das

2011

Cancer Metastasis Rev

Self Cite

View full text Add to dashboard Cite

Stem cells are pluripotent and expected to be of benefit in the management of coronary heart disease, stroke, diabetes mellitus, cancer, and Alzheimer's disease in which pro-inflammatory cytokines are increased. Identifying endogenous bioactive molecules that have a regulatory role in stem cell survival, proliferation, and differentiation may aid in the use of stem cells in various diseases including cancer. Essential fatty acids form precursors to both pro- and anti-inflammatory molecules have been shown to regulate gene expression, enzyme activity, modulate inflammation and immune response, gluconeogenesis via direct and indirect pathways, function directly as agonists of a number of G protein-coupled receptors, activate phosphatidylinositol 3-kinase/Akt and p44/42 mitogen-activated protein kinases, and stimulate cell proliferation via Ca(2+), phospholipase C/protein kinase, events that are also necessary for stem cell survival, proliferation, and differentiation. Hence, it is likely that bioactive lipids play a significant role in various diseases by modulating the proliferation and differentiation of embryonic stem cells in addition to their capacity to suppress inflammation. Ephrin Bs and reelin, adhesion molecules, and microRNAs regulate neuronal migration and cancer cell metastasis. Polyunsaturated fatty acids and their products seem to modulate the expression of ephrin Bs and reelin and several adhesion molecules and microRNAs suggesting that bioactive lipids participate in neuronal regeneration and stem cell proliferation, migration, and cancer cell metastasis. Thus, there appears to be a close interaction among essential fatty acids, their bioactive products, and inflammation and cancer growth and its metastasis.

show abstract

“…Lipoxins are a group of nonclassic eicosanoids that possess potent anti-inflammatory and proresolution properties [53][54][55][56][57][58] . Endometrium contains 15-LOX-2, an enzyme necessary for lipoxin biosynthesis.…”

Section: Ras Estrogen and Lipoxin A4mentioning

confidence: 99%

Renin–angiotensin–aldosterone system in insulin resistance and metabolic syndrome

Das¹

2016

Journal of Translational Internal Medicine

Self Cite

View full text Add to dashboard Cite

Obesity and its consequent complications such as hypertension and metabolic syndrome are increasing in incidence in almost all countries. Insulin resistance is common in obesity. Reninangiotensin system (RAS) is an important target in the treatment of hypertension and drugs that act on RAS improve insulin resistance and decrease the incidence of type 2 diabetes mellitus, explaining the close association between hypertension and type 2 diabetes mellitus. RAS influences food intake by modulating the hypothalamic expression of neuropeptide Y and orexins via AMPK dephosphorylation. Estrogen reduces appetite by its action on the brain in a way similar to leptin, an anorexigenic action that seems to be mediated via hypothalamic pro-opiomelanocortin (POMC) neurons in the arcuate nucleus and synaptic plasticity in the arcuate nucleus similar to leptin. Estrogen stimulates lipoxin A 4 , a potent vasodilator and platelet anti-aggregator. Since both RAS and estrogen act on the hypothalamic neuropeptides and regulate food intake and obesity, it is likely that RAS modulates LXA 4 synthesis. Thus, it is proposed that Angiotensin-II receptor blockers and angiotensin-converting enzymes and angiotensin-II antagonists may have the ability to augment LXA 4 synthesis and thus bring about their beneficial actions.

show abstract

Molecular Basis of Health and Disease

Cited by 62 publications

References 566 publications

Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids

Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids

Essential fatty acids and their metabolites as modulators of stem cell biology with reference to inflammation, cancer, and metastasis

Renin–angiotensin–aldosterone system in insulin resistance and metabolic syndrome

Contact Info

Product

Resources

About