Molecular Basis of Hexanoic Acid Taste in Drosophila melanogaster

Pradhan, Roshani Nhuchhen; Shrestha, Bhanu; Lee, Youngseok

doi:10.14348/molcells.2023.0035

Cited by 14 publications

(11 citation statements)

References 53 publications

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Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

“…At low concentrations (~0.1%), hexanoic acid elicits appetitive responses in Drosophila , while at high concentrations (~1–2%), it prompts aversion ( 74 ). Hexanoic acid attraction is driven by “sweet” GRNs, requiring both IR56d and Gr64d ( 72 – 74 , 131 , 132 ). Aversion to hexanoic acid is controlled by “bitter” GRNs via three bitter receptors: Gr32a, Gr33a, and Gr66a ( 74 ) ( Table 1 ).…”

Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

“…Hexanoic acid attraction is driven by “sweet” GRNs, requiring both IR56d and Gr64d ( 72 – 74 , 131 , 132 ). Aversion to hexanoic acid is controlled by “bitter” GRNs via three bitter receptors: Gr32a, Gr33a, and Gr66a ( 74 ) ( Table 1 ). Recent work has also demonstrated that the fly gustatory system can distinguish between different classes of fatty acids based on chain length ( 73 ).…”

Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

“…These findings indicate that IR56d is selective for MCFAs, while the co-receptors may function more broadly. However, a recent study questioned the involvement of IR25a and IR76b in the labellar response to the MCFA hexanoic acid ( 74 ). The molecular and cellular underpinnings of SCFA/LCFA detection and fatty acid discrimination remain unclear, but these complexities reflect a nuanced fatty acid taste encoding system that is sensitive to both concentration and subtle variations in molecular structure.…”

Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

“…Furthermore, one study showed that the sugar GR, Gr64e, is an essential component of MCFA signal transduction, unexpectedly serving as a downstream component in the PLC pathway within “sweet” GRNs ( 133 ). Notably, a recent investigation found that Gr64e mutation did not affect electrophysiological responses to the MCFA hexanoic acid ( 74 ). Despite this discrepancy, activation of a secondary receptor via PLC mimics the mammalian fatty acid signaling cascade.…”

Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

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Tastant-receptor interactions: insights from the fruit fly

Arntsen,

Guillemin,

Audette

et al. 2024

Front. Nutr.

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Across species, taste provides important chemical information about potential food sources and the surrounding environment. As details about the chemicals and receptors responsible for gustation are discovered, a complex view of the taste system is emerging with significant contributions from research using the fruit fly, Drosophila melanogaster, as a model organism. In this brief review, we summarize recent advances in Drosophila gustation and their relevance to taste research more broadly. Our goal is to highlight the molecular mechanisms underlying the first step of gustatory circuits: ligand-receptor interactions in primary taste cells. After an introduction to the Drosophila taste system and how it encodes the canonical taste modalities sweet, bitter, and salty, we describe recent insights into the complex nature of carboxylic acid and amino acid detection in the context of sour and umami taste, respectively. Our analysis extends to non-canonical taste modalities including metals, fatty acids, and bacterial components, and highlights unexpected receptors and signaling pathways that have recently been identified in Drosophila taste cells. Comparing the intricate molecular and cellular underpinnings of how ligands are detected in vivo in fruit flies reveals both specific and promiscuous receptor selectivity for taste encoding. Throughout this review, we compare and contextualize these Drosophila findings with mammalian research to not only emphasize the conservation of these chemosensory systems, but to demonstrate the power of this model organism in elucidating the neurobiology of taste and feeding.

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Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

Section: The Fruit Fly Taste Systemmentioning

confidence: 99%

See 3 more Smart Citations

Tastant-receptor interactions: insights from the fruit fly

Arntsen,

Guillemin,

Audette

et al. 2024

Front. Nutr.

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The power of Drosophila genetics in studying insect toxicology and chemical ecology

Huang,

Lee

2023

Crop Health

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Insect toxicology and chemical ecology are inherently interconnected disciplines, both dedicated to unraveling the intricate relationships between insects and the diverse array of chemical compounds that pervade their surroundings. Drosophila melanogaster, owing to its genetic and physiological similarities to other insects, serves as a robust model system in the study of insect toxicology. Moreover, state-of-the-art techniques in Drosophila neurobiology have extensively probed the chemosensory system of insects, providing significant insights into their adaptation to chemical environments. In this review, we emphasize the advancements achieved through the application of Drosophila genetics in investigations spanning both of these fields, significantly enhancing our understanding of the mode of action and resistance mechanisms of insecticides, as well as unraveling the molecular and cellular mechanisms underlying insect chemosensation and associated behaviors. The profound insights derived through this tiny fly not only enrich our understanding of the broader world of insects but also hold the potential to develop more effective and sustainable strategies for pest management.

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