Molecular basis of interchain disulfide-bond formation in BMP-9 and BMP-10
Tristin A. Schwartze,
Stefanie A. Morosky,
Teresa L. Rosato
et al.
Abstract:BMP-9 and BMP-10 are TGF-β family signaling ligands naturally secreted into blood. They act on endothelial cells and are required for proper development and maintenance of the vasculature. In hereditary hemorrhagic telangiectasia, regulation is disrupted due to mutations in the BMP-9/10 pathway, namely in the type I receptor ALK1 or the co-receptor endoglin. It has been demonstrated that BMP-9/10 heterodimers are the most abundant signaling species in the blood, but it is unclear how they form. Unlike other li… Show more
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