2007
DOI: 10.1002/jcb.21169
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Molecular basis of vanadium‐mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats

Abstract: Carcinogen-induced early DNA lesions and metallothionein (MT) over-expression have been implicated in cell proliferation and thereby subsequent expression of premalignant phenotype of the cell. We have therefore investigated the chemopreventive potential of vanadium in a multi-biomarker approach, viz. 8-hydroxy-2'-deoxyguanosines (8-OHdGs), DNA single-strand breaks (SSBs), DNA-protein crosslinks (DPCs), chromosomal aberrations (CAs), in situ MT expression, and cell proliferation in rat liver preneoplasia. Hepa… Show more

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Cited by 13 publications
(8 citation statements)
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References 51 publications
(52 reference statements)
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“…In chemically-induced tumor models in experimental animals, vanadium compounds show chemopreventive properties by means of optimization of phase I and phase II xenobiotic transformation enzymes (Bishayee et al, 2000;Ray et al, 2007;Chakraborty et al, 2007). Inorganic and organic vanadium compounds were tested in human tumor cell line models.…”
Section: Vanadium and Tumor Cellsmentioning
confidence: 99%
See 1 more Smart Citation
“…In chemically-induced tumor models in experimental animals, vanadium compounds show chemopreventive properties by means of optimization of phase I and phase II xenobiotic transformation enzymes (Bishayee et al, 2000;Ray et al, 2007;Chakraborty et al, 2007). Inorganic and organic vanadium compounds were tested in human tumor cell line models.…”
Section: Vanadium and Tumor Cellsmentioning
confidence: 99%
“…The above processes promote tumor cell growth at early stages of the disease and have an antitumor effect in the advanced stages of cancer. Studies in animals treated with carcinogens suggest that vanadium compounds used at low levels have selective effects on the tumor cells (Ray et al, 2007;Chakraborty et al, 2007).…”
Section: Figure 3 Some Antitumor and Cancerogenic Pathways Of Inorgamentioning
confidence: 99%
“…In addition, VCs stimulate the cell cycle, thus inhibiting apoptosis, as both processes are mutually connected [263]. In fact, there are studies in animals treated with carcinogens that suggest that VCs used at low levels have selective effects on the tumor cells [266,267]. One relevant issue is that frequently VCs cause much more DNA damage in tumor cells compared to non-tumor cells when present at the same levels.…”
Section: Vanadium In the Treatment Of Cancermentioning
confidence: 99%
“…The role of vanadium was investigated relatively extensively in hepatocarcinogenesis using rats as hosts and diethylnitrosamine (DEN, 200 mg/kg body weight) as a carcinogen [39,40]. In a long-term experiment, vanadium limited metallothionein (MT) expression and led to a restoration of hepatic levels of essential trace elements, decreased incidence of nodules by almost 60% and also of their multiplicity in experimental animals [39,41]. These results suggest a potential usefulness of vanadium for chemoprevention of liver cancer.…”
Section: Vanadium In Cancer Chemopreventionmentioning
confidence: 99%
“…These results suggest a potential usefulness of vanadium for chemoprevention of liver cancer. Further elucidation of the molecular mechanism of vanadium action in preventing carcinogenesis [41] indicates that supplementation of vanadium (0.5 ppm) abated the formation of 8-hydroxy-2'-deoxyguanosines (8-OHdGs) by 81%, formation of DNA single-strand breaks (ss-DNA), DNA-protein cross links (DPC) by 59% and chromosomal aberrations (CAs) by 72% in preneoplastic rat liver [41]. All of these findings point to vanadium, an easily available substance, being suitable for exploitation as a chemopreventive agent which can be supplemented as part of a daily diet.…”
Section: Vanadium In Cancer Chemopreventionmentioning
confidence: 99%