Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment

Moszczynska, Anna; Callan, Sean P.

doi:10.1124/jpet.116.238501

Cited by 118 publications

(94 citation statements)

References 292 publications

(412 reference statements)

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“…METH use produces also serious complications in multiple organs, beyond the brain . In fact, hyperthermia, hypertension, cardiac arrhythmia, seizures, cerebral hemorrhage, ischemic infarct, renal failure, liver damage, rhabdomyolysis, and wakefulness to the point of collapse and temporary blindness, coma, or death may ensue when METH overdose is in place …”

Section: Meth Clinical Featuresmentioning

confidence: 99%

The neurobiological mechanisms of physical exercise in methamphetamine addiction

et al. 2017

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Methamphetamine (METH) is the primary drug within amphetamine-type stimulants which are the second most abused group of drugs worldwide. There is no pharmacological treatment addressed specifically to METH addiction, and behavioral therapy is shadowed by poor long-term recovery and relapse. Therefore, novel approaches to manage METH addiction are an urgent need. This review aims to describe the current state of physical exercise use on methamphetamine addiction management. The following searching terms in PubMed were used: ("physical exercise" OR "exercise") AND "methamphetamine." Relevant references from key publications and gray literature were also reviewed to identify additional citations for inclusion. Original investigation regarding physical exercise and methamphetamine addiction (clinical data) or neurobiological mechanisms of physical exercise in animal models of methamphetamine administration (preclinical data) was included. Overall, METH users demonstrated improvements, including better fitness and emotional measures, lower relapse rates, and sustained abstinence when compared to nonexercised individuals. The neurobiological mechanisms of physical exercise in METH users seem to reflect an interplay of several agents, including neurochemicals, oxidative stress, neurogenesis, gliogenesis, and blood-brain barrier as disclosed by preclinical data. Exercise-based interventions alone or as a conjoint therapy may be a useful tool for managing METH addiction.

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Section: Meth Clinical Featuresmentioning

confidence: 99%

The neurobiological mechanisms of physical exercise in methamphetamine addiction

et al. 2017

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“…Higher doses of methamphetamine will cause aggressiveness, restlessness, repetitive behavior, agitation, confusion, anxiety, irritability, dysphoria, violent behavior, psychomotor impairment, stereotypy, auditory hallucinations, panic, and paranoia (36,37). During the end stage of a methamphetamine binge, euphoria is replaced by negative symptoms (e.g., anxiety, feelings of emptiness) and the appearance of most of the symptoms described above (33).…”

Section: Effects Of Methamphetaminementioning

confidence: 99%

“…Depressive symptoms are the hallmark of methamphetamine withdrawal, lasting beyond two weeks of abstinence (41,42). In this period, depression and anxiety may also lead to suicidal thoughts (33). Craving has been observed to last for at least 5 weeks, while users have been found particularly vulnerable to relapse during days 7 to 14 of abstinence (42).…”

Section: Withdrawal Of Methamphetaminementioning

confidence: 99%

“…Short-term effects of methamphetamine include euphoria, alertness, wakefulness, increased confidence, hyperactivity, and loss of appetite (33,34). Dopamine release is responsible for the euphoric effects of methamphetamine, but long-term use of methamphetamine causes molecular changes in the dopamine system, contributing to nerve terminal damage in the brain and leading to impaired motor skills, rapid cognitive decline, increased anxiety, psychotic disorders, violent behavior, hallucination, delusions and depression (35).…”

Section: Effects Of Methamphetaminementioning

confidence: 99%

“…Beyond psychiatric symptoms, physiological symptoms like loss of appetite, increased heart rate, blood pressure, and breathing rate as well as dilation of the pupils and raised body temperature, sweating, headache, blurred vision, dizziness, stomach cramps, muscle fatigue and cramps, chest pain and shaking, dehydration, nausea and vomiting (38), hyperthermia, hypertension, cardiac arrhythmia, seizures, cerebral hemorrhage, ischemic infarct, renal failure, rhabdomyolysis, and coma or death can also result from methamphetamine use (33,39,40).…”

Section: Effects Of Methamphetaminementioning

confidence: 99%

See 2 more Smart Citations

Update on methamphetamine: an old problem that we have recently encountered

Evren¹,

Bozkurt²

2018

Dusunen Adam

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Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder

2020

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In the wake of the opioid crisis, methamphetamine has reemerged as a challenge to mental health clinicians and researchers alike. Methamphetamine is now available in different forms such as ice, powder, and pills, with different pharmacokinetic characteristics that make them popular among certain types of individuals. 1 Recent seizure data suggest that methamphetamine production and trafficking are spreading into new areas of the globe. 2 According to the Automation of Reports and Consolidated Orders System, methamphetamine consumption increased 4-fold between 2015 and 2016 and total stimulant use doubled in the last decade. 3 From 2011 through 2016, the age-adjusted rate of drug overdose deaths involving methamphetamine more than tripled. 4 Moreover, drug overdose deaths involving cocaine, amphetamines, or both substances combined increased 42.4% from 12 122 in 2015 to 17 258 in 2016. 5 Based on the most recent data from the National Survey on Drug Use and Health, 6 the 12-month prevalence of individuals aged 12 years or older reporting methamphetamine use has increased by 195% from its low in 2010 to 2018 (Figure 1), and it is estimated that 1.86 million Americans used methamphetamine in 2018. These numbers underline the importance of paying attention to the possibility of the next substance use crisis. However, whereas opioid use disorder can be treated pharmacologically 7 and behaviorally, 8 there are significant challenges for the treatment of methamphetamine use disorder (MUD). This review focuses on 3 specific aspects of MUD. First, the neurobiology of methamphetamine is more complex than the traditional view of it as a monoaminergic modulator. Second, the clinical presentation is not limited to the symptoms associated with use disorder but extend to medical presentations, most notably the cardiovascular and cerebrovascular systems. Third, pharmacologic interventions focused on modulating the monoaminergic pathways have largely failed, and new pharmacologic approaches are necessary to focus on novel treatment targets. In the final section, several suggestions will be proposed for both clinicians and researchers to advance the understanding of MUD. Biological Pathways, Neural Basis, and CognitionMethamphetamine has been conceptualized primarily as a releaser of dopamine, serotonin, noradrenaline, and adrenaline from nerve terminals in the central and peripheral nervous system, 9 which occurs via several different mechanisms, including (1) redistributing catecholamines from synaptic vesicles to the cytosol, (2) reversing the plasma membrane transport of neurotransmitters, (3) blocking the activity of monoamine transporters, (4) decreasing the expression of dopamine transporters at the cell surface, (5) inhibiting monoamine oxidase activity, and (6) increasing the activity and IMPORTANCE The prevalence of and mortality associated with methamphetamine use has doubled during the past 10 years. There is evidence suggesting that methamphetamine use disorder could be the next substance use crisis in the United ...

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Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment

Cited by 118 publications

References 292 publications

The neurobiological mechanisms of physical exercise in methamphetamine addiction

The neurobiological mechanisms of physical exercise in methamphetamine addiction

Update on methamphetamine: an old problem that we have recently encountered

Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder

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