Molecular Biology and Genetics of Chordomas

Güdük, Mustafa; Özek, M. Memet

doi:10.1007/978-3-319-11274-9_44

Cited by 1 publication

(4 citation statements)

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“…22 Furthermore, fluorescence in situ hybridization showed dic(1;9)(p36.1;p21) clonal and nonclonal chromosomal rearrangements, with notable unbalanced translocation in chromosome 1p. 22 Since the genetics of chordoma is technical and beyond the scope of this historical paper, we recommend further reading regarding the genetics and biological basis of chordoma. 22,33…”

Section: History Of Diagnosismentioning

confidence: 99%

“…Our recent understanding of the genetics of chordoma stems from notable familial chordoma patients, starting with Foote and colleagues' discussion of a case involving middle-aged siblings experiencing familial sacrococcygeal chordomas, which paved the way for other discussions on familial cases. 22 Despite reports of congenital chordomas, the youngest reported patient with a positive family history was 3 years old. 22 Cytogenetic examinations of 2 daughters and their father suspected of familial chordoma showed karyotypic heterogenic hypo-or diploidy.…”

Section: History Of Diagnosismentioning

confidence: 99%

“…22 Despite reports of congenital chordomas, the youngest reported patient with a positive family history was 3 years old. 22 Cytogenetic examinations of 2 daughters and their father suspected of familial chordoma showed karyotypic heterogenic hypo-or diploidy. 22 Furthermore, fluorescence in situ hybridization showed dic(1;9)(p36.1;p21) clonal and nonclonal chromosomal rearrangements, with notable unbalanced translocation in chromosome 1p.…”

Section: History Of Diagnosismentioning

confidence: 99%

“…22 Since the genetics of chordoma is technical and beyond the scope of this historical paper, we recommend further reading regarding the genetics and biological basis of chordoma. 22,33…”

Section: History Of Diagnosismentioning

confidence: 99%

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A historical recount of chordoma

Sahyouni¹,

Goshtasbi²,

Mahmoodi

et al. 2018

Journal of Neurosurgery: Spine

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Chordoma, a rare bone tumor that occurs along the spine, has led scientists on a fascinating journey of discoveries. In this historical vignette, the authors track these discoveries in diagnosis and treatment, noting events and clinicians that played pivotal roles in our current understanding of chordoma. The study of chordoma begins in 1846 when Rudolf Virchow first observed its occurrence on a dorsum sellae; he coined the term “chordomata” 11 years later. The chordoma’s origin was greatly disputed by members of the scientific community. Eventually, Müller’s notochord hypothesis was accepted 36 years after its proposal. Chordomas were considered benign and slow growing until the early 1900s, when reported autopsy cases drew attention to their possible malignant nature. Between 1864 and 1919, the first-ever symptomatic descriptions of various forms of chordoma were reported, with the subsequent characterization of chordoma histology and the establishment of classification criteria shortly thereafter. The authors discuss the critical historical steps in diagnosis and treatment, as well as pioneering operations and treatment modalities, noting the physicians and cases responsible for advancing our understanding of chordoma.

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Section: History Of Diagnosismentioning

confidence: 99%

Section: History Of Diagnosismentioning

confidence: 99%

Section: History Of Diagnosismentioning

confidence: 99%

“…22 Since the genetics of chordoma is technical and beyond the scope of this historical paper, we recommend further reading regarding the genetics and biological basis of chordoma. 22,33…”

Section: History Of Diagnosismentioning

confidence: 99%

See 2 more Smart Citations