1995
DOI: 10.1099/13500872-141-4-755
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Molecular biology of aflatoxin biosynthesis

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Cited by 176 publications
(129 citation statements)
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“…Hence, an action level of 20 ppb for total AFs in foods for human consumption has been imposed by Food and Drug Administration (FDA) in the United States and by regulatory agencies in many other countries. The biosynthetic pathway of AF is one of the best known pathways of secondary metabolism in microorganisms (Trail et al, 1995). Our current understanding about chemistry and molecular biology of AF biosynthesis is a direct consequence of bioconversion experiments using several blocked mutants as well as successful cloning and characterization of the majority of the AF biosynthetic pathway genes (Georgianna and Payne, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Hence, an action level of 20 ppb for total AFs in foods for human consumption has been imposed by Food and Drug Administration (FDA) in the United States and by regulatory agencies in many other countries. The biosynthetic pathway of AF is one of the best known pathways of secondary metabolism in microorganisms (Trail et al, 1995). Our current understanding about chemistry and molecular biology of AF biosynthesis is a direct consequence of bioconversion experiments using several blocked mutants as well as successful cloning and characterization of the majority of the AF biosynthetic pathway genes (Georgianna and Payne, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…All the tested concentrations inhibited aflatoxin production, and these concentrations were not cytotoxic. These results suggest that AE may be acting in the fungal secondary metabolism, through the inactivation of some enzyme involved in the biosynthetic pathway (1,15) or acting on the genic expression (11). Therefore, Polymnia sonchifolia could be a promising plant control production of aflatoxin B1.…”
Section: Resultsmentioning
confidence: 99%
“…Aflatoxins are mycotoxins produced by certain strains of Aspergillus flavus and Aspergillus parasiticus (2,15). Ingestion of food highly contaminated with aflatoxins may originate acute toxicity including hepatotoxicity, teratogenicity, immunotoxicity and even death.…”
Section: Introductionmentioning
confidence: 99%
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“…Aspergillus flavus and Aspergillus parasiticus have the ability to colonize oil seed crops of agricultural importance, such as corn, cotton, peanuts, sorghum and tree nuts. Ingestion of aflatoxin contaminated food can cause hepatocellular carcinoma, immunotoxicity, and teratogenic effects (Dvorackova and Kusak, 1990;Trail et al, 1995;Wogan et al, 1992). Various developed countries have strict regulation on the amount of AF allowed in food commodities.…”
Section: Introductionmentioning
confidence: 99%