Molecular Biology of Allergens: Structure and Immune Recognition

Chapman, Martin D.; Pomés, Anna; Aalberse, Rob C.

doi:10.1007/978-4-431-72802-3_16

Cited by 2 publications

(1 citation statement)

References 123 publications

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“…Allergens are a diverse group of proteins with different structures and biological functions [32–39] . To date more than a hundred entries of non-redundant allergen structures (i.e., dismissing isoforms and point mutants) have been deposited in the protein data bank (PDB).…”

Section: Structural Families Of Allergensmentioning

confidence: 99%

Structure of allergens and structure based epitope predictions

Dall’Antonia

Pavkov‐Keller

Zangger

et al. 2014

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The structure determination of major allergens is a prerequisite for analyzing surface exposed areas of the allergen and for mapping conformational epitopes. These may be determined by experimental methods including crystallographic and NMR-based approaches or predicted by computational methods. In this review we summarize the existing structural information on allergens and their classification in protein fold families. The currently available allergen-antibody complexes are described and the experimentally obtained epitopes compared. Furthermore we discuss established methods for linear and conformational epitope mapping, putting special emphasis on a recently developed approach, which uses the structural similarity of proteins in combination with the experimental cross-reactivity data for epitope prediction.

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Section: Structural Families Of Allergensmentioning

confidence: 99%