Molecular Biology of Histamine System, Volume 1

Chazot, Paul L.

doi:10.3390/ijms23095026

IJMS

2022

DOI: 10.3390/ijms23095026

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Molecular Biology of Histamine System, Volume 1

Paul L. Chazot

Abstract: Histamine is arguably the most pleiotropic transmitted in the human body[…]

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2024

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Immunomodulatory Role of Histamine in Oncoimmunology and Immunotherapy

Shawky

2024

Advances in Medical Diagnosis, Treatment, and Care

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The complexity of cancer biology exceeds the uncontrolled proliferation of neonatal cells to include the crosstalk between tumors and their microenvironments (TME). Specifically, the histamine-producing cells constitute a key component of TME given their “immunoediting” role that would ultimately determine the disease outcome. Histamine is not only one of the potent mediators that intensify/perpetuate the inflammatory responses; it also exerts a plethora of fine-tuned immunoregulatory effects through coupling with G-protein coupled receptors (HRs) ubiquitously distributed on almost all mammalian cells. In the context of cancer biology, histamine plays a multifaceted role in tumor progression, where it acts as a pro- or anti-tumorigenic mediator depending on the cancer type and the cognate receptor. This chapter addresses the immunomodulatory role of histamine and its cognate receptors in tumor immunobiology, in addition to compiling cutting-edge approaches to their potential use as adjuvants in cancer immunotherapy.

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Immunomodulatory Role of Histamine in Oncoimmunology and Immunotherapy

Shawky

2024

Advances in Medical Diagnosis, Treatment, and Care

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Molecular Biology of Histamine System, Volume 1

Abstract: Histamine is arguably the most pleiotropic transmitted in the human body[…]

Cited by 1 publication

References 8 publications

Immunomodulatory Role of Histamine in Oncoimmunology and Immunotherapy

Immunomodulatory Role of Histamine in Oncoimmunology and Immunotherapy

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