Molecular biology, phytochemistry and bioactivity of three endemic <i>Aloe</i> species from Mauritius and Réunion Islands

Ranghoo-Sanmukhiya, Mala; Govinden-Soulange, Joyce; Lavergne, Christophe; Khoyratty, S.; Silva, Denis Da; Frédérich, Michel; Kodja, Hippolyte

doi:10.1002/pca.1234

Cited by 20 publications

(8 citation statements)

References 24 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Mascarene Islands, aloe leaves are widely used to treat cutaneous bacterial infections and boils, and they are also taken as an antispasmodic during menstruation (Ranghoo-Sanmukhiya et al, 2010). Aloes are also used for traditional medicine to treat sexually-transmitted diseases such as HIV/ AIDS despite a lack of scientific evidence to support their efficacy (Campbell-Barker, 2009;Nyika, 2007).…”

Section: Aloes As Medicinal Plantsmentioning

confidence: 99%

African aloe ecology: A review

Cousins

Witkowski

2012

Journal of Arid Environments

View full text Add to dashboard Cite

Section: Aloes As Medicinal Plantsmentioning

confidence: 99%

African aloe ecology: A review

Cousins

Witkowski

2012

Journal of Arid Environments

View full text Add to dashboard Cite

“…In the Mascarene Islands, leaves of Aloe species are used for their cutaneous healing properties [2]. Aloe leaves contain two different parts: the gel and the leaf exudate.…”

Section: Of 25mentioning

confidence: 99%

LC-MS Based Phytochemical Profiling towards the Identification of Antioxidant Markers in Some Endemic Aloe Species from Mascarene Islands

Breaud

Lallemand²,

Mares³

et al. 2022

Antioxidants

Self Cite

View full text Add to dashboard Cite

Aloe plant species have been used for centuries in traditional medicine and are reported to be an important source of natural products. However, despite the large number of species within the Aloe genus, only a few have been investigated chemotaxonomically. A Molecular Network approach was used to highlight the different chemical classes characterizing the leaves of five Aloe species: Aloe macra, Aloe vera, Aloe tormentorii, Aloe ferox, and Aloe purpurea. Aloe macra, A. tormentorii, and A. purpurea are endemic from the Mascarene Islands comprising Reunion, Mauritius, and Rodrigues. UHPLC-MS/MS analysis followed by a dereplication process allowed the characterization of 93 metabolites. The newly developed MolNotator algorithm was usedfor molecular networking and allowed a better exploration of the Aloe metabolome chemodiversity. The five species appeared rich in polyphenols (anthracene derivatives, flavonoids, phenolic acids). Therefore, the total phenolic content and antioxidant activity of the five species were evaluated, and a DPPH-On-Line-HPLC assay was used to determine the metabolites responsible for the radical scavenging activity. The use of computational tools allowed a better description of the comparative phytochemical profiling of five Aloe species, which showed differences in their metabolite composition, both qualitative and quantitative. Moreover, the molecular network approach combined with the On-Line-HPLC assay allowed the identification of 9 metabolites responsible for the antioxidant activity. Two of them, aloeresin A and coumaroylaloesin, could be the principal metabolites responsible for the activity. From 374 metabolites calculated by MolNator, 93 could be characterized. Therefore, the Aloe species can be a rich source of new chemical structures that need to be discovered.

show abstract

“…Phytochemical analyses shows the presence of flavonoids, alkaloids, terpenoids, saponin, tannin, steroids, glycosides, etc. [24][25][26] In the phytochemical analysis, the presence or absence of phytochemicals even for one plant is based on basic parameters. ( 1) Plant parts such as leaf (gel, latex, or skin), root, or flowers, (2) solvent used for extraction (methanol, ethanol, ethyl acetate, chloroform, hexane, etc.…”

Section: Preparation Of Aloe Extractsmentioning

confidence: 99%

A Review on Antimalarial Activities of Aloe species Extracts

Yadeta¹

2022

JCD

View full text Add to dashboard Cite

Among the most prevalent diseases caused by protozoan parasites, the parasites of the genus Plasmodium cause malaria. Malaria is transmitted to humans by the infected female anopheles mosquito. Malaria is a vector-borne disease and it continues to have devastating effects on people’s lives, especially in developing countries. To control malaria, many popular practices exist to avoid the nuisance of mosquito bites such as fumigation, burning green leaves on the hut’s threshold, mosquito coils, insecticide sprays, and repellents. Due to the vast metabolic diversity of plants, natural products may offer relatively cheaper and an easy alternative treatment opportunity to treat malaria. The genus Aloe is one of the top medicinal plants that has maintained its popularity over the course of time. Aloe in one form or another is a common domestic medicine and is the basis of most pharmaceutical preparations. Various components present in the Aloe species have been found effective against many diseases, including malaria. Although most of the antimalarial activities were based on in vivo tests, in vitrotests were also analyzed by certain researchers. The leaf latex in all Aloespecies and the isolated compounds displayed antimalarial activity in a dose-independent manner. Considering that natural molecules have acted as natural templates in the development of antimalarial agents, it is encouraged to investigate further analyses into Aloe constituents and their values against malaria. It should be followed with phytochemical and pharmacological analyses to give scientific ground to medicinal knowledge and future potential utilization.

show abstract

Molecular biology, phytochemistry and bioactivity of three endemic Aloe species from Mauritius and Réunion Islands

Abstract: This study is the first report highlighting the differences between Aloe sp.p from Mascarene and Aloe vera at the metabolic and genomic level.

Cited by 20 publications

References 24 publications

African aloe ecology: A review

African aloe ecology: A review

LC-MS Based Phytochemical Profiling towards the Identification of Antioxidant Markers in Some Endemic Aloe Species from Mascarene Islands

A Review on Antimalarial Activities of Aloe species Extracts

Contact Info

Product

Resources

About