Molecular Biomarkers in Clinical Development: What Could we Learn from the Clinical Trial Registry?

Deyati, Avisek; Sanam, Rama Devi; Guggilla, Sreenivasa Rao; Pidugu, Vijaya Rao; Novac, Natalia

doi:10.2217/pme.14.27

Cited by 2 publications

(1 citation statement)

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“…The other compounds are undergoing clinical trials. The database shows an increasing number of studies dedicated to the development and research of new oncological drugs and it is estimated that breast cancer research accounted for 28% of all of such studies [ 46 ]. The clinical studies described herein that are designed to select effective drugs for breast cancer chemoprevention have been conducted over the last decade.…”

Section: Breast Cancer Preventionmentioning

confidence: 99%

Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs?

2020

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Breast cancer is the most prevalent type of cancer among women worldwide. There are several recommended methods of breast cancer prevention, including chemoprevention. There are several approved drugs used to prevent breast cancer occurrence or recurrence and metastasizing. There are also a number of new substances undergoing clinical trials and at the stage of initial study. Studies suggest that dietary factors play a crucial role in breast cancer etiology. Epidemiological studies indicate that in particular vegetables from the Brassicaceae family are a rich source of chemopreventive substances, with sulforaphane (SFN) being one of the most widely studied and characterized. This review discusses potential applicability of SFN in breast cancer chemoprevention. A comprehensive review of the literature on the impact of SFN on molecular signalling pathways in breast cancer and breast untransformed cells is presented. The presented results of in vitro and in vivo studies show that this molecule has a potential to act as a preventive molecule either to prevent disease development or recurrence and metastasizing, and as a compound protecting normal cells against the toxic effects of cytostatics. Finally, the still scanty attempts to develop an improved analog are also presented and discussed.

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Section: Breast Cancer Preventionmentioning

confidence: 99%