Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia

Ranganath, Kushi; Feng, Allen L.; Franco, Ramon A.; Varvares, Mark A.; Faquin, William C.; Naunheim, Matthew R.; Saladi, Srinivas Vinod

doi:10.3390/cancers14225581

Cited by 6 publications

(4 citation statements)

References 142 publications

(165 reference statements)

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“…In an attempt to overcome the subjectivity of OED histopathological grading, which frequently fails to predict malignant transformation, efforts have been made to associate particular genetic changes with histomorphological grades. 18 Several studies have proposed PDPN as a marker that has the potential to enhance the diagnosis of OED when combined with histomorphological evaluation. Additionally, PDPN plays a crucial role in assessing the MTP of oral potentially malignant lesions (OPMLs), a determination often elusive through histopathological evaluation alone.…”

Section: Discussionmentioning

confidence: 99%

Association of podoplanin expression to histopathological grades of oral epithelial dysplasia and oral squamous cell carcinoma

Shabir,

Haider Durrani,

Tariq

et al. 2024

J Pak Med Assoc

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Objective: To determine the expression of podoplanin, and to correlate it with histopathological grades in oral epithelial dysplasia and oral squamous cell carcinoma cases. Methods: The retrospective, analytical, cross-sectional study was conducted at the City Laboratory, Peshawar, Pakistan, and comprised specimen block data of histologically diagnosed cases of oral benign lesions, dysplastic lesions and oral squamous cell carcinoma from January 2017 to August 2021. Two sections (4um) were cut from each specimen block for Haematoxylin and Eosin staining and immunohistochemistry. The slides were re-evaluated by two pathologists for confirmation of the diagnosis, and podoplanin marker was applied to cases selected using immunohistochemistry. Data was analysed using SPSS 22. Results: Of the 80 cases identified, 68(85%) were analysed. There were 20(29.4%) benign cases; 11(55%) females and 9(45%) males with mean age 39.90±16.23 years, 20(29.4%) oral dysplastic cases; 14(70%) males and 6(30%) females with mean age 57.75±12.02 years, and 28(41.2%) oral squamous cell carcinoma cases; 17(61%) males and 11(39%) females with mean age 50.55±14.80 years. Podoplanin expression in oral epithelial dysplasia cases was significant (p=0.028), while it was not significant in the other 2 groups (p>0.05). Conclusion: Podoplanin when used along with histopathological evaluation could help in the diagnosis and grading of oral epithelial dysplasia lesions. Key Words: Oral epithelial dysplasia, Oral squamous cell carcinoma, Podoplanin.

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Section: Discussionmentioning

confidence: 99%

Association of podoplanin expression to histopathological grades of oral epithelial dysplasia and oral squamous cell carcinoma

Shabir,

Haider Durrani,

Tariq

et al. 2024

J Pak Med Assoc

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“…The identification and validation of molecular biomarkers have the potential to improve diagnostic accuracy, risk stratification, and personalized management approaches for patients with OPMDs. 34…”

Section: ø Non-invasive Diagnostic Techniquesmentioning

confidence: 99%

Oral Potentially Malignant Disorders: A Comprehensive Review of Diagnostic Approaches and Management Strategies

Anjum,

Sheikh

2024

J. Bahria Uni. Med. Dent. Coll.

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Oral potentially malignant disorders (OPMDs) encompass a group of conditions that have an increased risk of progressing to oral cancer. Timely diagnosis and effective management of these disorders play a crucial role in preventing malignant transformation and improving patient outcomes. This review article provides a comprehensive overview of the diagnostic approaches and management strategies for OPMDs. It discusses the current understanding of OPMDs, highlights the various diagnostic methods available, and explores the evolving landscape of management options. The aim of this review is to enhance the knowledge and awareness of healthcare professionals involved in oral pathology and promote effective decisionmaking in the diagnosis and management of OPMDs. A thorough understanding of diagnostic approaches and management strategies for oral potentially malignant disorders is essential for dental and medical professionals involved in oral pathology. This review article provides a comprehensive overview of the topic, highlighting the importance of early detection, risk assessment, and interdisciplinary collaboration

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“…Unlike cSCCs, one of the main factors affecting the low survival rate of HNSCC, is the high percentage of diagnosis at advanced stage, being the recurrence rate of about 50% during the first 2 years from diagnosis. For this reason, several clinical and/or pathological parameters have been indicated to predict prognosis, recurrence, and survival, and to drive the therapeutic choice [31][32][33][34][35][36][37]. Notably, cSCCs and HNSCCs display hallmarks of solid tumors mildly responsive to systemic immunotherapy [38][39][40][41][42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Serine and one-carbon metabolism sustain non-melanoma skin cancer progression

et al. 2023

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Non-melanoma skin cancer (NMSC) is a tumor that arises from human keratinocytes, showing abnormal control of cell proliferation and aberrant stratification. Cutaneous basal cell carcinoma (cBCC) and cutaneous squamous cell carcinoma (cSCC) are the most common sub-types of NMSC. From a molecular point of view, we are still far from fully understanding the molecular mechanisms behind the onset and progression of NMSC and to unravel targetable vulnerabilities to leverage for their treatment, which is still essentially based on surgery. Under this assumption, it is still not elucidated how the central cellular metabolism, a potential therapeutical target, is involved in NMSC progression. Therefore, our work is based on the characterization of the serine anabolism/catabolism and/or one-carbon metabolism (OCM) role in NMSC pathogenesis. Expression and protein analysis of normal skin and NMSC samples show the alteration of the expression of two enzymes involved in the serine metabolism and OCM, the Serine Hydroxy-Methyl Transferase 2 (SHMT2) and Methylen-ThetraHydroFolate dehydrogenase/cyclohydrolase 2 (MTHFD2). Tissues analysis shows that these two enzymes are mainly expressed in the proliferative areas of cBCC and in the poorly differentiated areas of cSCC, suggesting their role in tumor proliferation maintenance. Moreover, in vitro silencing of SHMT2 and MTHFD2 impairs the proliferation of epidermoid cancer cell line. Taken together these data allow us to link the central cellular metabolism (serine and/or OCM) and NMSC proliferation and progression, offering the opportunity to modulate pharmacologically the involved enzymes activity against this type of human cancer.

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Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia

Cited by 6 publications

References 142 publications

Association of podoplanin expression to histopathological grades of oral epithelial dysplasia and oral squamous cell carcinoma

Association of podoplanin expression to histopathological grades of oral epithelial dysplasia and oral squamous cell carcinoma

Oral Potentially Malignant Disorders: A Comprehensive Review of Diagnostic Approaches and Management Strategies

Serine and one-carbon metabolism sustain non-melanoma skin cancer progression

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