Molecular changes in hippocampal energy metabolism in mice selectively bred for extremes in stress reactivity: Relevance of mitochondrial dysfunction for affective disorders

Abstract

Affective disorders, such as major depression, are frequently associated with metabolic disturbances involving mitochondria. Although dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is known to alter energy metabolism, the precise mechanisms linking stress and metabolic disturbances are not sufficiently understood. We used a mouse model of affective disorders to investigate the impact of a genetic predisposition for extremes in stress reactivity on behavioural and metabolic phenotypes as well as energy metabolism.

Genetically predisposed and resilient animal models of depression reveal divergent responses to early-life adversity

“…1-Monopalmitin is a lipid responsible for amongst others, storing energy and acting as a structural component of cell membranes (Qin et al, 2021). Consequently, that MSEW induced a reduction in hippocampal 1-monopalmitin of FSL rats (Table 3) could suggest a negative effect on mitochondrial function and is strongly supported by the robust preoteomics analysis of Mallei et al (2015) on the Flinders strain and recent findings linking stress-related pathways, stress reactivity and the effects on mitochondrial function (Rappeneau et al, 2023). Nevertheless, it is worth noting that despite their not being any statistical strain differences in hippocampal 1-monopalmitin levels, O' Gorman et al (2017) reported plasma 1-monopalmitin levels to be reduced in children and adolescents suffering from psychotic disorders.…”