Molecular characterisation of genital human papillomavirus among women in Southwestern, Nigeria

Nejo, Yewande T.; Olaleye, David O.; Odaibo, Georgina N.

doi:10.1371/journal.pone.0224748

Cited by 28 publications

(29 citation statements)

References 69 publications

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“…However, the present study revealed no significant correlation between parity and HPV infection rate. Although, our results are consistent with results of previous studies indicating that there is no significant association between HPV infection and parity, there are still insufficient data to precisely determine the effect of parity on the risk of HPV infections. Close monitoring of HPV infection in women in China is recommended because of the replacement of the one‐child policy with a universal two‐child policy …”

Section: Discussionsupporting

confidence: 90%

Prevalence and genotype distribution of human papillomavirus infection among women: A population‐based study in Dali Bai Autonomous Prefecture, Yunnan Province, China

Zhou

et al. 2019

Journal of Medical Virology

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Accumulating evidence indicates that persistent infection with high-risk oncogenic human papillomavirus (HPV) genotypes is the most important risk factor for cervical cancer, and that the distribution of HPV genotypes varies regionally. This study explored the prevalence and genotype distribution of HPV infection among Han, Yi, and Bai women in various regions of Dali Bai Autonomous Prefecture, Yunnan Province, China. This cross-sectional study included 2779 women (20-76 years old) who were referred for 21-HPV genotype array diagnostic from five regions of Dali Bai Autonomous Prefecture between February 2013 and May 2016. Statistical methods used included a the χ 2 test, Fisherʼs exact test, t test, and logistic regression.Overall HPV prevalence in the study population was 7.6%. HPV-52, HPV-58, HPV-18, HPV-81, and HPV-16 were the most prevalent genotypes in the study area, and notably, the prevalence of HPV-58 was significantly higher among women in Heqing County than that in other regions. Univariate analysis showed that husband's age, region, fertility status, and parity were potential factors associated with HPV infection. Multivariate logistic regression analysis revealed that Heqing County was an independent risk factor for HPV infection among women in the Dali area, moreover, Yi women showed the highest risk for HPV infections. Overall, our finding emphasizing the urgent need for an HPV screening and prevention program in Heqing County and Yi women. We also suggest that HPV-related health education should be provided not only to women, but also to men, to reduce the risk of infection in women. K E Y W O R D S epidemiology, ethnic, genotype distribution, human papillomavirus

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Section: Discussionsupporting

confidence: 90%

Prevalence and genotype distribution of human papillomavirus infection among women: A population‐based study in Dali Bai Autonomous Prefecture, Yunnan Province, China

Zhou

et al. 2019

Journal of Medical Virology

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“…Similar results have been reported in previous research studies in American and British populations 37,38 . Studies showing an effect of race and social class on HPV prevalence are often not comparable due to differences in the included population [39][40][41] , which is generally limited to specific groups. Behavioral characteristics, such as smoking and number of partners, may explain differences in prevalence rates according to region.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HPV infection among sexually active adolescents and young adults in Brazil: The POP-Brazil Study

Wendland

Villa

Unger

et al. 2020

Sci Rep

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& pop-Brazil Study Group 1 † For Brazil, there are no nationwide data on HPV prevalence against which the impact of the HPV immunization program can be measured in the future. Therefore, we aim to evaluate the prevalence of genital HPV infection among adolescents and young adults in Brazil. A cross-sectional, multicentric, nationwide survey was conducted between September 2016 and November 2017. Sexually active unvaccinated women and men aged 16 to 25 years old were recruited from 119 public primary care units, including all 26 state capitals and the Federal District. All participants answered a face-to-face interview and provided biological samples for genital HPV analysis. We used an automated DNA extraction method and HPV genotyping was performed using the Linear Array genotyping test (Roche). Of 7,694 participants, 53.6% (95% CI 51.4-55.8) were positive for any HPV type. The prevalence of highrisk HPV types was significantly higher in women (38.6% vs. 29.2%, P < 0•001). The HPV types included in the quadrivalent vaccine were detected in 1002 (14.8%) specimens, with a different pattern of HPV infection between sexes. Characteristics associated with overall HPV detection included female gender, self-declaration of race as brown/pardo, lower socioeconomic class, single or dating, current smoking and having 2 or more sex partners in the past year. We found a high prevalence of HPV, with significant differences between regions. Our data provide information that may be considered when developing HPV prevention policies and constitute a baseline against which the impact of the HPV immunization program in Brazil can be measured in future years. Human papillomavirus (HPV) is globally the most common sexually transmitted infection 1 , and it is strongly associated with cervical, anogenital and oropharyngeal cancers 2,3. HPV is one of the main causes of mortality among women in underdeveloped countries 1,4,5. Although the prevalence of HPV has already been evaluated in some specific groups and regions, there are no data on HPV prevalence in young general populations of the different regions of Brazil 6. The prevalence and types of circulating HPV vary widely both among different populations and among age groups within populations. All regions of the world have shown an overall decline in prevalence according to age, except Latin America and the Caribbean, where the prevalence increases later in life, presenting a bi-modal distribution 1. In addition, the prevalence and type-specific HPV frequency can change according to race, with a higher incidence in indigenous 7 and black populations 8. The introduction of HPV vaccination is an opportunity to prevent infection and associated lesions, thus changing the patterns of mortality by cervical cancer. Brazil introduced an HPV immunization program using a quadrivalent vaccine in 2014 for children 9 to 14 years old and is currently adopting a 2-dose vaccination schedule (0-6 months) 9. Although vaccine efficacy in decrease cervical intraepithelial neoplasia has been demonstrated

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“…For data or data subsets of the same population that were published in multiple reports [13,14], the articles were independently considered based on the different primers which were used to determine dissimilar overall HPV prevalence. While one study [13] reported the HPV genotype distribution, the other study [14] which involved the same population reported the cervical cancer screening data. One study [15] included data from Nigeria Women representing multiple states of the Federal Republic of which was data from one of the states were captured in another study [16].…”

Section: Data Itemsmentioning

confidence: 99%

“…Data were collated from studies conducted between 2004 [18] and 2019 [13,[19][20][21][22]. Except for the southeastern region of Nigeria where there were no data generated, all HPV genotyping of Nigerian participants were conducted in laboratories in North-central [15,16,20], North-east [23], North-west [15,22] and South-west [13,14,17,18,24] and South-south [25]. Two studies reported multiple infections with any specific HPV-type.…”

Section: Study Characteristicsmentioning

confidence: 99%

The pattern of human papillomavirus infection and genotypes among Nigerian women from 1999 to 2019: a systematic review

et al. 2021

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Background: There are no robust national prevalence of Human Papillomavirus (HPV) genotypes in Nigerian women despite the high burden of cervical cancer morbidity and mortality. The objective of study: This study aims to determine the pooled prevalence and risk factors of genital HPV infection in Nigeria through a systemic review protocol. Methods: Databases including PubMed, Scopus, Google Scholar and AJOL were searched between 10 April to 28 July 2020. HPV studies on Nigerian females and published from April 1999 to March 2019 were included. GRADE was used to assess the quality of evidence. Results: The pooled prevalence of cervical HPV was 20.65% (95%CI: 19.7-21.7). Genotypes 31 (70.8%), 35 (69.9%) and 16 (52.9%) were the most predominant HPV in circulation. Of the six geopolitical zones in Nigeria, northeast had the highest pooled prevalence of HPV infection (48.1%), while the least was in the north-west (6.8%). After multivariate logistic regression, duration (years) of sexual exposure (OR ¼ 3.24, 95%CI: 1.78-9.23]), history of other malignancies (OR ¼ 1.93, 95%CI: 1.03-2.97]), history of sexually transmitted infection (OR ¼ 2.45, 95% CI: 1.31-3.55]), coital frequency per week (OR ¼ 5.11, 95%CI: 3.86-14.29), the status of circumcision of the sexual partner (OR ¼ 2.71, 95%CI: 1.62-9.05), and marital status (OR ¼ 1.72, 95%CI: 1.16-4.72), were significant risk factors of HPV infection (p < 0.05). Irregular menstruation, postcoital bleeding and abdominal vaginal discharge were significantly associated with HPV infection (p < 0.05). Conclusion: HPV prevalence is high in Nigeria and was significantly associated with several associated risk factors. Rapid screening for high-risk HPV genotypes is recommended and multivalent HPV vaccines should be considered for women.

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Molecular characterisation of genital human papillomavirus among women in Southwestern, Nigeria

Cited by 28 publications

References 69 publications

Prevalence and genotype distribution of human papillomavirus infection among women: A population‐based study in Dali Bai Autonomous Prefecture, Yunnan Province, China

Prevalence and genotype distribution of human papillomavirus infection among women: A population‐based study in Dali Bai Autonomous Prefecture, Yunnan Province, China

Prevalence of HPV infection among sexually active adolescents and young adults in Brazil: The POP-Brazil Study

The pattern of human papillomavirus infection and genotypes among Nigerian women from 1999 to 2019: a systematic review

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