Molecular characteristics of mumps viruses isolated in Taiwan from 2006 to 2016

Cheng, Wei-Jen; Liu, Ming‐Tsan

doi:10.1016/j.heliyon.2018.e00518

Cited by 5 publications

(10 citation statements)

References 37 publications

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“…The nucleotide sequence of our strain has been submitted to the DNA Data Bank of Japan (DDBJ) with accession no. LC486118 and J but not genotype F [11,13]. The genotype F strain found in this study may have been brought over to Sabah by travelers from regions with circulating genotype F MuV.…”

Section: Discussionmentioning

confidence: 60%

“…Genotype F has limited circulation and has been endemic in China since its discovery in 1995 [ 10 , 11 ]. Although genotype F has occasionally been found in other countries in North America, Europe and Asia, the MuV strains from these countries were epidemiologically linked to China [ 12 , 13 ]. Interestingly, the MuV strain detected in this study did not only cluster with strains from China but also phylogenetically related to a strain from Canada, where the patient had a travel history to India [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previously, only genotypes G and J were found circulating in Malaysia [ 11 ]. Cheng and Liu isolated a genotype G strain in Taiwan from a patient who travelled to Malaysia in 2006, implying that G MuVs circulated in Malaysia in 2006 [ 13 ]. Other Southeast Asian countries including Indonesia, Thailand, and Singapore also reported the occurrence of genotypes G and J but not genotype F [ 11 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cheng and Liu isolated a genotype G strain in Taiwan from a patient who travelled to Malaysia in 2006, implying that G MuVs circulated in Malaysia in 2006 [ 13 ]. Other Southeast Asian countries including Indonesia, Thailand, and Singapore also reported the occurrence of genotypes G and J but not genotype F [ 11 , 13 ]. The genotype F strain found in this study may have been brought over to Sabah by travelers from regions with circulating genotype F MuV.…”

Section: Discussionmentioning

confidence: 99%

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Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo

et al. 2022

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Background In October 2016, a mumps outbreak occurred among the students living in the on-campus dormitory of a public university located in Kota Kinabalu, Sabah, Malaysia. This study aimed to investigate the outbreak and identify the genotype of the mumps virus (MuV) strain that was involved in the outbreak. Main body During the outbreak, one 21-year-old and four 20-year-old males staying in the same dormitory building were reported to have developed symptoms of mumps. Of these, two students were available during the investigation for sample collection to detect MuV by reverse transcription polymerase chain reaction (RT-PCR) of the 639-bp fragment encompassing the entire small hydrophobic (SH) gene. Nucleotide sequencing of the amplicon and phylogenetic analysis using the neighbor-joining method was performed to determine the MuV genotype. Of the two buccal swab samples, one was positive for MuV. The MuV strain in this sample belonged to genotype F and it was clustered together with genotype F strains from China with 96.84–99.68% nucleotide identity. Conclusions Genotype F has limited circulation and is endemic in mainland China. Genotype F strains occasionally reported from other countries were epidemiologically linked to China. This study is the first to report a case of genotype F MuV in Malaysia and no epidemiological link could be established with mainland China. The results provide important information that can assist in strategic planning to improve the prevention and control of mumps infection in Malaysia.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo

et al. 2022

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“…Mostly, these outbreaks had been caused by the global genotype G. Apart from genotype G single outbreaks were caused by genotype H MuV. Recently, outbreaks were also caused by genotype K MuV in Eastern Asia [ 12 ].…”

Section: The Mumps Virus and Its Genotypesmentioning

confidence: 99%

Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany

Beleni

Borgmann

2018

IJERPH

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Vaccination against mumps virus (MuV) (mostly measles-mumps-rubella) is routinely performed in more than 120 countries and has resulted in a distinct decrease of mumps incidence. However, alteration of mumps epidemiology has been observed in several countries after implementation of the vaccine but is sparsely documented. Moreover, outbreaks have occurred after starting vaccination, even in highly vaccinated populations. In the former German Democratic Republic (DDR) mumps was a notifiable disease but vaccination against mumps was not implemented. In the five eastern German states forming the DDR until 1990, mumps was not notifiable until 2001. Except for the lack of reporting between 1990–2000, data from Eastern Germany allow analysis of mumps epidemiology after initiating the vaccination campaign. For the period from 2001 to 2016 the data show that the incidence of mumps dropped notably after initiating vaccines, and was accompanied by an increase of the median age of patients with mumps. In Eastern Germany, no outbreaks were noted, while several outbreaks occurred in Western Germany, possibly due to a lower vaccination rate. Further literature analysis revealed that outbreaks were facilitated by waning immunity and crowding. Nevertheless, although vaccination prevented infection, the course of illness, once infected, was sometimes more complicated. In comparison to non-vaccinated populations, high rates of complicated courses occurred and were marked by orchitis, due to higher age of mumps patients. Therefore, refusing vaccination against mumps increases the risk of severe courses when living in a vaccinated population.

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Nationwide and long-term molecular epidemiologic studies of mumps viruses that circulated in Japan between 1986 and 2017

Kidokoro¹,

Shiino²,

Yamaguchi³

et al. 2022

Front. Microbiol.

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In Japan, major mumps outbreaks still occur every 4–5 years because of low mumps vaccine coverage (30–40%) owing to the voluntary immunization program. Herein, to prepare for a regular immunization program, we aimed to reveal the nationwide and long-term molecular epidemiological trends of the mumps virus (MuV) in Japan. Additionally, we performed whole-genome sequencing (WGS) using next-generation sequencing to assess results from conventional genotyping using MuV sequences of the small-hydrophobic (SH) gene. We analyzed 1,064 SH gene sequences from mumps clinical samples and MuV isolates collected from 25 prefectures from 1986 to 2017. The results showed that six genotypes, namely B (110), F (1), G (900), H (3), J (41), and L (9) were identified, and the dominant genotypes changed every decade in Japan since the 1980s. Genotype G has been exclusively circulating since the early 2000s. Seven clades were identified for genotype G using SH sequence-based classification. To verify the results, we performed WGS on 77 representative isolates of genotype G using NGS and phylogenetically analyzed them. Five clades were identified with high bootstrap values and designated as Japanese clade (JPC)-1, -2, -3, -4, -5. JPC-1 and -3 accounted for over 80% of the total genotype G isolates (68.3 and 13.8%, respectively). Of these, JPC-2 and -5, were newly identified clades in Japan through this study. This is the first report describing the nationwide and long-term molecular epidemiology of MuV in Japan. The results provide information about Japanese domestic genotypes, which is essential for evaluating the mumps elimination progress in Japan after the forthcoming introduction of the mumps vaccine into Japan’s regular immunization program. Furthermore, the study shows that WGS analysis using NGS is more accurate than results obtained from conventional SH sequence-based classification and is a powerful tool for accurate molecular epidemiology studies.

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Molecular characteristics of mumps viruses isolated in Taiwan from 2006 to 2016

Cited by 5 publications

References 37 publications

Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo

Mumps outbreak in university students: first detection of mumps virus genotype F in Borneo

Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany

Nationwide and long-term molecular epidemiologic studies of mumps viruses that circulated in Japan between 1986 and 2017

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