Molecular Characteristics of N1-Methyladenosine Regulators and Their Correlation with Overall Cancer Survival

Li, Juan; Zhang, Chun‐Ting; Yuan, Xin; Cao, Yuan

doi:10.1089/dna.2020.6214

Cited by 18 publications

(13 citation statements)

References 54 publications

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“…The importance of RNA methylation in the occurrence and progression of cancer has long been recognized, and there have been over 170 different RNA chemical alterations discovered to date, with m6A, N1-methyladenosine (m1A), and 5-methylcytosine (m5C) being the most well-studied ( Esteve-Puig et al, 2020 ). From previous studies, Figures 6A–C compile the correlations among SRR and RNA methylation modification-related genes ( Li et al, 2019 ; Du et al, 2020 ; Li et al, 2021 ). According to the correlation heatmap, the m6A-methylation-related genes covering writers (RBM15B, ZC3H13, and RBMX), readers (YTHDC1, YTHDC2, YTHDF2, HNRNPC, and HNRNPA2B1), and erasers (FTO and ALKBH5) showed significant and positive correlations with one another.…”

Section: Resultsmentioning

confidence: 99%

Integrated Bioinformatics Analysis of Serine Racemase as an Independent Prognostic Biomarker in Endometrial Cancer

Cui

Wang

et al. 2022

Front. Genet.

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Endometrial cancer (EC) kills about 76,000 women worldwide, with the highest incidence in industrialized countries. Because of the rise in disease mortality and new diagnoses, EC is now a top priority for women’s health. Serine racemase (SRR) is thought to play a role in the central nervous system, but its role in cancers, particularly in EC, is largely unknown. The current study starts with a pan-cancer examination of SRR’s expression and prognostic value before delving into SRR’s potential cancer-suppressing effect in patients with EC. SRR may affect the endometrial tumor immune microenvironment, according to subsequent immune-related analysis. SRR expression is also linked to several genes involved in specific pathways such as ferroptosis, N6-methyladenosine methylation, and DNA damage repair. Finally, we used the expression, correlation, and survival analyses to investigate the upstream potential regulatory non-coding RNAs of SRR. Overall, our findings highlight the prognostic significance of SRR in patients with EC, and we can formulate a reasonable hypothesis that SRR influences metabolism and obstructs key carcinogenic processes in EC.

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Section: Resultsmentioning

confidence: 99%

Integrated Bioinformatics Analysis of Serine Racemase as an Independent Prognostic Biomarker in Endometrial Cancer

Cui

Wang

et al. 2022

Front. Genet.

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“…Li et al. ( 23 ) systematically analyzed the association of the molecular alterations of m1A regulators and the clinical data of 33 cancer types from the TCGA. This group found that m1A regulatory protein expression was correlated with various carcinogenic pathways and patient overall survival, indicating that m1A regulators have the potential for prognostic prediction in many types of cancer and may now provide new treatment strategies ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

A Novel m1A-Score Model Correlated With the Immune Microenvironment Predicts Prognosis in Hepatocellular Carcinoma

2022

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RNA methylation plays crucial roles in gene expression and has been indicated to be involved in tumorigenesis, while it is still unclear whether m1A modifications have potential roles in the prognosis of hepatocellular carcinoma (HCC). In this study, we comprehensively analyzed RNA sequencing (RNA-seq) data and clinical information using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We collected 10 m1A regulators and performed consensus clustering to determine m1A modification patterns in HCC. The CIBERSORT method was utilized to evaluate the level of immune cell infiltration. Principal component analysis was used to construct the m1A-score model. In the TCGA-LIHC cohort, the expression of all 10 m1A regulators was higher in tumor tissues than in normal control tissues, and 8 of 10 genes were closely related to the prognosis of HCC patients. Two distinct m1A methylation modification patterns (Clusters C1 and C2) were identified by the 10 regulators and were associated with different overall survival, TNM stage and tumor microenvironment (TME) characteristics. Based on the differentially expressed genes (DEGs) between C1 and C2, we identified three gene clusters (Clusters A, B and C). C1 with a better prognosis was mainly distributed in Cluster C, while Cluster A contained the fewest samples of C1. An m1A-score model was constructed using five m1A regulators related to prognosis. Patients with higher m1A scores showed a poorer prognosis than those with lower scores in the TCGA-LIHC and GSE14520 datasets. In conclusions, our study showed the vital role of m1A modification in the TME and progression of HCC. Quantitative evaluation of the m1A modification patterns of individual patients facilitates the development of more effective biomarkers for predicting the prognosis of patients with HCC.

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“…Some studies revealed that m 1 A methylation modifications influence different cancers including hepatocellular carcinoma (HCC), lung cancer, colorectal cancer and pancreatic cancer (Wang et al, 2020;Shi et al, 2020;Xie et al, 2020). In addition, Li et al found that expression of m 1 A regulatory factors are significantly altered in cancer patients and are closely related to changes in carcinogenic pathways and overall survival rate (Li et al, 2021). Zhao et al comprehensively analyzed TCGA data for diagnosed with esophageal carcinoma (ESCA), liver hepatocellular carcinoma (LIHC), stomach adenocarcinoma (STAD), pancreatic adenocarcinoma (PAAD) and colorectal adenocarcinoma (COAD)).…”

Section: The Role Of N 1 -Methyladenosine In Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Section: Adenine-related Rna Modification Regulation In Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

et al. 2021

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood. Modifications on RNA are involved in many pathophysiological processes, such as tumor development and inflammation. Adenosine-related RNA modifications have shown to be linked to cancer and may play a role in cancer occurrence and development. To date, there are at least 170 different chemical RNA modifications that modify coding and non-coding RNAs (ncRNAs). These modifications affect RNA stability and transcription efficiency. In this review, we focus on the current understanding of the four major RNA adenosine modifications (N6-Methyladenosine, N1-Methyladenosine, Alternative Polyadenylation Modification and A-to-I RNA editing) and their potential molecular mechanisms related to HNSCC development and progression. We also touch on how these RNA modifications affect treatment of HNSCCs.

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Molecular Characteristics of N1-Methyladenosine Regulators and Their Correlation with Overall Cancer Survival

Cited by 18 publications

References 54 publications

Integrated Bioinformatics Analysis of Serine Racemase as an Independent Prognostic Biomarker in Endometrial Cancer

Integrated Bioinformatics Analysis of Serine Racemase as an Independent Prognostic Biomarker in Endometrial Cancer

A Novel m1A-Score Model Correlated With the Immune Microenvironment Predicts Prognosis in Hepatocellular Carcinoma

Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

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