“…At present, shellfish allergens have been widely identified, including tropomyosin (TM), arginine kinase, myosin light chain, sarcoplasmic calcium-binding protein, paramyosin, and filamin C, which could cause different degrees of sensitization. TM is a pan-allergen with high allergenicity in shellfish, which consists of two α-helical polypeptide subunits forming a stable coiled coil, whereas it typically exists as one subunit with a molecular weight of 32∼40 kDa in invertebrates. , However, TM with different subunits was gradually identified in shellfish, but the immunoreactivity differences of these subunits have not been fully elucidated. , Thus, a more extensive study of TM in H.…”