2018
DOI: 10.1007/s00705-018-4076-3
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Molecular characterization and phylogenetic analysis of very virulent infectious bursal disease virus circulating in Morocco during 2016-2017

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Cited by 12 publications
(4 citation statements)
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“…Hence, the IBDV quasispecies cloud composition relies more on the capacity of the polymerase to generate the mutant spectra than the mechanism of replication per se. This characteristic is reflected in the mutation rate of IBDV, which has been reported, as a consensus, in the order of approximately 10 −4 substitutions/site/year [47,62,63], which is one order of magnitude lower than most of the quasispecies viruses [64]. In addition, IBDV shows one of the higher mutation rates in the polymerase gene, as determined by Gao et al [62], concurring with the results of the current study.…”
Section: Discussionsupporting
confidence: 92%
“…Hence, the IBDV quasispecies cloud composition relies more on the capacity of the polymerase to generate the mutant spectra than the mechanism of replication per se. This characteristic is reflected in the mutation rate of IBDV, which has been reported, as a consensus, in the order of approximately 10 −4 substitutions/site/year [47,62,63], which is one order of magnitude lower than most of the quasispecies viruses [64]. In addition, IBDV shows one of the higher mutation rates in the polymerase gene, as determined by Gao et al [62], concurring with the results of the current study.…”
Section: Discussionsupporting
confidence: 92%
“…Indeed, Gumboro disease has been endemic in Morocco since it was first detected in commercial poultry flocks in 1978. Recently, the highly virulent strain very virulent IBDV has been isolated and characterized in many regions of the country, demonstrating that this strain, which is distinct from classic and vaccine strains, is widespread [ 36 ]. Our observation of a high seroprevalence of IBDV in this backyard production system is in agreement with previous serological studies conducted in different countries.…”
Section: Discussionmentioning
confidence: 99%
“…The primers and probes used as described by [25]. The reaction mixtures and the thermal cycling used in this study followed the protocol as described by [19].…”
Section: Morphometric Measurementsmentioning
confidence: 99%
“…This is why the evaluation of IBDV virulence is very important to understand its epidemiology and contribute to the e cient prevention and control. vvIBDV genotype was detected in broilers ocks in different parts of Morocco, based on the molecular characterization of hypervariable region of VP2 [19].…”
Section: Introductionmentioning
confidence: 99%