Molecular characterization of a novel Camelus dromedarius papillomavirus

Sobhy, Nader M.; Singh, Vikash; Damaty, Hend M. El; Mor, Sunil K.; Youssef, Christiana Rezk Bottros; Goyal, Sagar M.

doi:10.1016/j.cimid.2020.101561

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Members of PVs infect the skin and mucosal surfaces of diverse animal hosts[ 15 ], typically resulting in benign mucosal and skin lesions[ 3 ]. The core ORFs of papillomavirus include E1, E2, L1 and L2.…”

Section: Discussionmentioning

confidence: 99%

“…Members of the family Papillomaviridae are non-enveloped, small, circular viruses with double-stranded (ds) DNA genomes of approximately 5.7 to 8.6 kilobases (kb) in size[ 1 ]. Papillomaviruses (PVs) are capable of infecting the skin and mucosal surfaces of mammals and many other vertebrates in a host-specific manner and can cause papilloma or fibromyoidoma in humans, animals, and birds[ 2 , 3 ]. However, there are several studies that have identified PVs in healthy skin[ 4 ] and mucous membranes[ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library

Zhu

Dai

2023

Virol J

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Here, using viral metagenomic method, a novel whale papillomavirus (temporarily named wPV, GenBank accession number OP856597) was discovered in a whale (Delphinapterus leucas) pharyngeal metagenomic library. The complete genome size of wPV is 7179 bp, with GC content of 54.4% and a nucleotide composition of 23.4% A, 22.3% T, 28.4% G, and 25.9% C. The viral genome has a typical papillomavirus organization pattern, and five ORFs were predicted, including two late genes encoding L1 and L2, and three early genes encoding E1, E2, and E6. Pairwise sequence comparison and phylogenetic analysis based on the L1 gene sequence indicated that wPV may be a novel species within genus Dyodeltapapillomavirus. In addition, the E2 region of wPV was predicted to have a potential recombination event. The discovery of this novel papillomavirus increases our understanding of the viral ecology of marine mammals, providing insights into possible future infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library

Zhu

Dai

2023

Virol J

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“…We observed some dromedary camels showing some skin lesions and warts in different regions of the head (Figure 1). There are several viruses causing skin tumours in dromedary camels such as camel poxvirus, Orf [contagious pustular dermatitis] and camel papillomavirus (Alajlan & Alsubeeh, 2020; Duraffour et al., 2011; Sobhy et al., 2020). These viral infections induce various forms of skin lesions in camels.…”

Section: Discussionmentioning

confidence: 99%

Betaretrovirus infections in dromedary camels in Saudi Arabia

Hemida

Alnaeem

2022

Veterinary Medicine & Sci

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Background: Retroviral infections have been reported in many species of animals, especially cattle, sheep and goats. However, there are no available reports about retrovirus infection in dromedary camels. Several dromedary camels showed visible tumorlike lesions on and around the nostrils as well as around the eyes.Objectives: Following are the objectives: to identify the causative agents of these identified tumours in dromedary camels and to perform molecular characterization of the detected strains of the causative agent. Methods:We extracted the nucleic acids from some fresh lesions out of these animals, and then amplified some key retrovirus genes. We amplified several regions of the rotavirus genome using the PCR technique. The obtained sequences were assembled and the phylogenetic trees were conducted per each target retrovirus gene. Results:Our results revealed a high degree of identity to some retroviruses of sheep.Phylogenetic analysis based on some retrovirus genes revealed that the causative agents of these lesions are closely related to sheep retroviruses, particularly the Jaagsiekte sheep Retrovirus (JSRV) and the ENTV. Conclusions:To the best of our knowledge, this is the first report of retrovirus infections in dromedary camels in the Arabian Peninsula. This highlights the possible species jump for the retrovirus from sheep and goats to the dromedary camels, which live in close proximity with these animals in many parts of the world, especially the Arabian Peninsula.

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Camel Papillomatosis

Khalafalla¹

2021

Infectious Diseases of Dromedary Camels

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Molecular characterization of a novel Camelus dromedarius papillomavirus

Cited by 3 publications

References 32 publications

Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library

Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library

Betaretrovirus infections in dromedary camels in Saudi Arabia

Camel Papillomatosis

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