Molecular characterization of a novel aspartyl aminopeptidase that contributes to the increase in glutamic acid content in chicken meat during cooking

Yuhara, Hitomi; Ohtani, Akira; Matano, Mami; Kashiwagi, Yutaka; Maehashi, Kenji

doi:10.1016/j.fochms.2021.100015

Cited by 1 publication

(1 citation statement)

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“…Several genes are of particular interest due to their presence across breeds and they include SLC4A2 (solute carrier family 4 member 2) on chromosome 2, CCNB3 (cyclin B3) on chromosome 4, and DNPEP (aspartyl aminopeptidase) on chromosome 7. These genes have been linked to muscle development and tissue-specific biological processes in muscle [ 63 ]. Noteworthy, the gene encoding the miRNA MIR6683 is present in CNVR 621 which has been identified in the BSA, MER, MUG, PPA, SIC and VLP breeds, and is associated with sex determination (Additional file 5 ) [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-wide investigation to assess copy number variants in the Italian local chicken population

Cendron,

Cassandro,

Penasa

2024

J Animal Sci Biotechnol

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Background Copy number variants (CNV) hold significant functional and evolutionary importance. Numerous ongoing CNV studies aim to elucidate the etiology of human diseases and gain insights into the population structure of livestock. High-density chips have enabled the detection of CNV with increased resolution, leading to the identification of even small CNV. This study aimed to identify CNV in local Italian chicken breeds and investigate their distribution across the genome. Results Copy number variants were mainly distributed across the first six chromosomes and primarily associated with loss type CNV. The majority of CNV in the investigated breeds were of types 0 and 1, and the minimum length of CNV was significantly larger than that reported in previous studies. Interestingly, a high proportion of the length of chromosome 16 was covered by copy number variation regions (CNVR), with the major histocompatibility complex being the likely cause. Among the genes identified within CNVR, only those present in at least five animals across breeds (n = 95) were discussed to reduce the focus on redundant CNV. Some of these genes have been associated to functional traits in chickens. Notably, several CNVR on different chromosomes harbor genes related to muscle development, tissue-specific biological processes, heat stress resistance, and immune response. Quantitative trait loci (QTL) were also analyzed to investigate potential overlapping with the identified CNVR: 54 out of the 95 gene-containing regions overlapped with 428 QTL associated to body weight and size, carcass characteristics, egg production, egg components, fat deposition, and feed intake. Conclusions The genomic phenomena reported in this study that can cause changes in the distribution of CNV within the genome over time and the comparison of these differences in CNVR of the local chicken breeds could help in preserving these genetic resources.

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Section: Discussionmentioning

confidence: 99%